monoclonal antibody

plural monoclonal antibodies

Definition of monoclonal antibody

: an antibody that is derived from the clone of a single B cell and that is produced in large quantities of identical cells possessing affinity for the same epitope on a specific antigen (as a cancer cell)

Note: Monoclonal antibodies are typically used in immunotherapy (such as in the treatment of autoimmune or inflammatory disorders and cancer), diagnostic testing, and cell identification and tracing. Hybridoma cell lines are typically employed to produce an unlimited supply of monoclonal antibodies.

Researchers studying this and other cancers have long sought to use monoclonal antibodies—biological molecules that bind only to particular target cells—to attack tumors directly or to shuttle toxins selectively to cancer cells.— R. Weiss The ideal immunosuppressive monoclonal antibody would be one that abrogates responses to a defined antigen and preserves responses to all others.— Thomas A. Waldmann The drug, which would be given by intravenous infusion every four weeks, is a monoclonal antibody that tamps down the immune system …— Andrew Pollack abbreviation Mab, mAb, MAB, mab

First Known Use of monoclonal antibody

1967, in the meaning defined above

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The first known use of monoclonal antibody was in 1967

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Cite this Entry

“Monoclonal antibody.” Dictionary, Merriam-Webster, Accessed 11 Jul. 2020.

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