epitope

noun
epi·​tope | \ ˈe-pə-ˌtōp How to pronounce epitope (audio) \

Definition of epitope

: a molecular region on the surface of an antigen capable of eliciting an immune response and of combining with the specific antibody produced by such a response

called also determinant, antigenic determinant

Examples of epitope in a Sentence

Recent Examples on the Web On the top of the protein, a spot called an epitope serves as a landing pad for antibodies, allowing the virus to be neutralized. Lawrence Wright, The New Yorker, "The Plague Year," 28 Dec. 2020 Unlike monoclonal antibodies, which are being developed to target a specific molecular region, or epitope, on the surface of SARS-CoV-2 to elicit an immune response, horse polyclonal antibodies against SARS-CoV-2 recognize multiple epitopes. Debbie Ponchner, Scientific American, "Costa Rica Readies Horse Antibodies for Trials as an Inexpensive COVID-19 Therapy," 17 Aug. 2020 The observation of this study raised the alarm that Sars-CoV-2 mutation that varied epitope (something that an antibody attaches itself to) profile could arise at any time. Barnini Chakraborty, Fox News, "Mutation strain from India could kill current research efforts for coronavirus vaccine: report," 15 Apr. 2020 Additional attributes are the potential for epitope spread by increasing cross-reactivity to other virus strains, which can have a direct impact on breadth of virus coverage and enhanced cellular immunity13. William Warren, Scientific American, "Sanofi Pasteur: fighting influenza by improving today and innovating for tomorrow," 18 Sep. 2019 The epitopes flagged the bacteria, triggering white cells and othe immune fighters to attack. Jason Daley, Smithsonian, "New “Immunobiotic” Could Treat Antibiotic-Resistant Superbugs," 6 July 2018 A fragment of the chemical that gives rise to insulin, the peptide (known to chemists by the catchy moniker GSLQPLALEGSLQKRGIV) is called an epitope. Melissa Healy, The Seattle Times, "Study finds immunotherapy may prevent Type 1 diabetes," 9 Aug. 2017 A fragment of the chemical that gives rise to insulin, the peptide (known to chemists by the catchy moniker GSLQPLALEGSLQKRGIV) is called an epitope. Melissa Healy, latimes.com, "Immunotherapy succeeds in thwarting Type-1 diabetes in study," 9 Aug. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'epitope.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of epitope

1960, in the meaning defined above

History and Etymology for epitope

epi- + Greek tópos "place"

Note: Term introduced by the Danish immunologist Niels Kaj Jerne (1911-94) in "Immunological speculations," Annual Review of Microbiology, vol. 14 (1960), pp. 341-58.

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Time Traveler for epitope

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The first known use of epitope was in 1960

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Cite this Entry

“Epitope.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/epitope. Accessed 11 May. 2021.

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More Definitions for epitope

epitope

noun
epi·​tope | \ ˈep-ə-ˌtōp How to pronounce epitope (audio) \

Medical Definition of epitope

: a molecular region on the surface of an antigen capable of eliciting an immune response and of combining with the specific antibody produced by such a response

called also determinant, antigenic determinant

More from Merriam-Webster on epitope

Britannica.com: Encyclopedia article about epitope

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