epitope

noun
epi·​tope | \ ˈe-pə-ˌtōp How to pronounce epitope (audio) \

Definition of epitope

: a molecular region on the surface of an antigen capable of eliciting an immune response and of combining with the specific antibody produced by such a response

called also determinant, antigenic determinant

Examples of epitope in a Sentence

Recent Examples on the Web One potential benefit might be longer-lasting protection, Greenberger speculated, since the coronavirus is unlikely to mutate every protein epitope included in this vaccine. Angus Chen, STAT, 14 Apr. 2022 This mAb, derived from B cells of a patient who recovered from SARS-1 in 2003, targets an epitope on the S protein that is conserved in the sarbecovirus family. Laura Defrancesco, Scientific American, 6 Jan. 2022 The portion of the pathogen's protein that the antibody recognizes is called an epitope. John Timmer, Ars Technica, 13 Jan. 2022 Sequence conservation at the BG10-19 epitope explains the cross-neutralization against SARS-1, as 23 of 29 residues are conserved between SARS-1 and SARS-CoV-2 RBDs. William A. Haseltine, Forbes, 11 May 2021 On the top of the protein, a spot called an epitope serves as a landing pad for antibodies, allowing the virus to be neutralized. Lawrence Wright, The New Yorker, 28 Dec. 2020 Unlike monoclonal antibodies, which are being developed to target a specific molecular region, or epitope, on the surface of SARS-CoV-2 to elicit an immune response, horse polyclonal antibodies against SARS-CoV-2 recognize multiple epitopes. Debbie Ponchner, Scientific American, 17 Aug. 2020 The observation of this study raised the alarm that Sars-CoV-2 mutation that varied epitope (something that an antibody attaches itself to) profile could arise at any time. Barnini Chakraborty, Fox News, 15 Apr. 2020 Additional attributes are the potential for epitope spread by increasing cross-reactivity to other virus strains, which can have a direct impact on breadth of virus coverage and enhanced cellular immunity13. William Warren, Scientific American, 18 Sep. 2019 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'epitope.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of epitope

1960, in the meaning defined above

History and Etymology for epitope

epi- + Greek tópos "place"

Note: Term introduced by the Danish immunologist Niels Kaj Jerne (1911-94) in "Immunological speculations," Annual Review of Microbiology, vol. 14 (1960), pp. 341-58.

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Time Traveler for epitope

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The first known use of epitope was in 1960

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Dictionary Entries Near epitope

Epitonium

epitope

epitoxoid

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Cite this Entry

“Epitope.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/epitope. Accessed 16 Aug. 2022.

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More Definitions for epitope

epitope

noun
epi·​tope | \ ˈep-ə-ˌtōp How to pronounce epitope (audio) \

Medical Definition of epitope

: a molecular region on the surface of an antigen capable of eliciting an immune response and of combining with the specific antibody produced by such a response

called also determinant, antigenic determinant

More from Merriam-Webster on epitope

Britannica.com: Encyclopedia article about epitope

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