2
: an abnormal change in structure of an organ or part due to injury or disease
especially
: one that is circumscribed (see circumscribe sense 1) and well defined
Examples of lesion in a Sentence
Recent Examples on the Web
Her eldest daughter, 15-year-old Camille, has a brain lesion that causes severe epilepsy and needs to stay close to her neurologist.
—
Lauren Villagran, USA Today, 26 Oct. 2025
Follow-up MRIs during the next several years showed no new lesions on my brain or my spine.
—Lucinda Rosenfeld, New Yorker, 25 Oct. 2025
It may be yellowed, have dark spots or sunken lesions, Kondrat says.
—Leanne Potts, Better Homes & Gardens, 23 Oct. 2025
Previously, during a routine physical in 2023, another cancerous skin lesion had been successfully removed with similar follow-up.
—Gabe Whisnant, MSNBC Newsweek, 20 Oct. 2025
See All Example Sentences for lesion
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Lauren Villagran, USA Today, 26 Oct. 2025
Follow-up MRIs during the next several years showed no new lesions on my brain or my spine.
—Lucinda Rosenfeld, New Yorker, 25 Oct. 2025
It may be yellowed, have dark spots or sunken lesions, Kondrat says.
—Leanne Potts, Better Homes & Gardens, 23 Oct. 2025
Previously, during a routine physical in 2023, another cancerous skin lesion had been successfully removed with similar follow-up.
—Gabe Whisnant, MSNBC Newsweek, 20 Oct. 2025
See All Example Sentences for lesion
Cite this Entry
“Lesion.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/lesion. Accessed 30 Oct. 2025.
Copy CitationKids Definition
lesion
noun
le·sion
ˈlē-zhən 
: a change in the structure of a bodily organ or part due to injury or disease
especially
: an injured or diseased spot or area clearly marked off from healthy tissue around it
Medical Definition
Legal Definition
lesion
noun
le·sion
ˈlē-zhən
in the civil law of Louisiana
: loss from failure to receive a threshold amount or value (as one-half market value) for immovable property conveyed or transferred by a commutative contract (as a sale or exchange)
called also lesion beyond moiety
compare unjust enrichmentEtymology
Anglo-French, damage, injury, from Latin laesio, from laedere to injure
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