isotretinoin

noun

iso·​tret·​i·​noin ˌī-sō-ˈtre-tə-ˌnȯin 

: a cis isomer of retinoic acid that is a synthetic derivative of vitamin A, inhibits sebaceous gland function and keratinization, and is used in the treatment of severe inflammatory acne but is contraindicated in pregnancy because of its implication as a cause of birth defects

Examples of isotretinoin in a Sentence

Recent Examples on the Web

Today, isotretinoin still stands to be the most clinically effective treatment for severe acne. —Caroline C. Boyle, USA Today, 11 Apr. 2025

Inflammation of the lips (a.k.a. cheilitis) can be one of the most annoying side effects of isotretinoin. —Sara Coughlin, SELF, 30 Apr. 2025

Derivatives of vitamin A, such as isotretinoin, can treat acne.7 4. —Allison Herries, Verywell Health, 16 Apr. 2025

Due to isotretinoin’s high risk of causing birth defects, strict protocols have been established to ensure that patients, especially those who can become pregnant, adhere to safety measures during treatment. —Leslie Baumann, Miami Herald, 2 Apr. 2025

Word History

First Known Use

1979, in the meaning defined above

Rhymes for isotretinoin

• bryozoan
• metazoan
• protozoan
• coan
• kohen
• rohan
• rowan
• rowen
• minoan
• samoan

Medical Definition

isotretinoin

noun

iso·​tret·​i·​noin ˌī-sō-ˈtret-ə-ˌnȯin 

: a cis isomer of retinoic acid that is a synthetic derivative of vitamin A, that inhibits sebaceous gland function and keratinization, and that is administered in the treatment of severe inflammatory acne but is contraindicated in pregnancy because of its implication as a cause of birth defects

called also 13-cis-retinoic acid, retinoic acid

see accutane