Definition of isotretinoin
: a cis isomer of retinoic acid that is a synthetic derivative of vitamin A, inhibits sebaceous gland function and keratinization, and is used in the treatment of severe inflammatory acne but is contraindicated in pregnancy because of its implication as a cause of birth defects
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Merriam-Webster unabridged
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Time Traveler for isotretinoin
The first known use of isotretinoin was in 1979
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