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Taking vitamin D supplements with thiazide diuretics can increase calcium absorption, causing hypercalcemia.—Amy Brownstein, Verywell Health, 27 Feb. 2026 According to Tan, hypercalcemia is riskiest for people with chronic kidney disease, which can affect the kidneys’ ability to convert vitamin D to calcitriol, as well as those who have difficulty absorbing the vitamin.—Julia Ries Wexler, Health, 28 Jan. 2026