thal·​as·​se·​mia | \ˌtha-lə-ˈsē-mē-ə \

Definition of thalassemia 

: any of a group of inherited disorders of hemoglobin synthesis (such as Cooley's anemia) that are marked by mild to severe hypochromic and microcytic anemia, result from the partial or complete failure in production of one or more globin chains, and tend to occur especially in individuals of Mediterranean, African, or southeastern Asian ancestry sometimes used with a prefix (such as alpha-, beta-, or delta-) to indicate the hemoglobin chain affected — see beta-thalassemia

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Other Words from thalassemia

thalassemic \ˌtha-​lə-​ˈsē-​mik \ adjective or noun

Examples of thalassemia in a Sentence

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Acceleron and Celgene are conducting a second Phase 3 clinical trial of luspatercept in patients with beta-thalassemia, another blood disease. Adam Feuerstein, STAT, "Acceleron blood disease drug hits goal in pivotal clinical trial," 28 June 2018 On Monday night, Celgene and Acceleron said their partnered drug luspatercept met all primary and secondary endpoints in a Phase 3 clinical trial of patients with transfusion-dependent beta thalassemia. Adam Feuerstein, STAT, "Celgene is perking up. Here’s what needs to happen for the momentum to continue," 10 July 2018 The results: Seven of the eight beta-thalassemia patients no longer need chronic blood transfusions and all have normal hemoglobin levels. Adam Feuerstein, STAT, "New Bluebird data show promising benefits for gene therapy, if they last," 15 June 2018 This type of gene disruption — called non-homologous end joining — is being used in sickle-cell and thalassemia trials. Fox News, "Futuristic gene-editing technology may cause cancer," 13 June 2018 Between 60% and 80% of beta-thalassemia patients require regular red blood cell transfusions, which have serious side effects such as iron toxicity. Sarah Toy, WSJ, "Gene Therapy Shows Promise in Patients with a Blood Disorder," 19 Apr. 2018 Aliyana has sickle beta plus thalassemia, a form that is often considered milder. Cassie Owens,, "This Bucks County teen isn't letting sickle cell stop her pageant dreams," 17 May 2018 Most people with severe anemia from thalassemia require red blood cell transfusions every two to three weeks. Jacqueline Howard, CNN, "Gene therapy helps patients avoid blood transfusion," 18 Apr. 2018 Cesar was diagnosed at birth with thalassemia, a blood disease. Rachelle Krygier, Washington Post, "Venezuela faces a terrible new crisis: A critical shortage of blood," 8 Mar. 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'thalassemia.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of thalassemia

1932, in the meaning defined above

History and Etymology for thalassemia

New Latin, from Greek thalassa sea + New Latin -emia

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The first known use of thalassemia was in 1932

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variants: or British thalassaemia \ˌthal-​ə-​ˈsē-​mē-​ə \

Medical Definition of thalassemia 

: any of a group of inherited hypochromic anemias and especially Cooley's anemia controlled by a series of allelic genes that cause reduction in or failure of synthesis of one of the globin chains making up hemoglobin and that tend to occur especially in individuals of Mediterranean, African, or southeastern Asian ancestry sometimes used with a prefix (as alpha-, beta-, or delta-) to indicate the hemoglobin chain affected

called also Mediterranean anemia

— see alpha-thalassemia, beta-thalassemia

More from Merriam-Webster on thalassemia

Rhyming Dictionary: Words that rhyme with thalassemia Encyclopedia article about thalassemia

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