Medical Dictionary

alpha–thalassemia

noun al·pha–thal·as·se·mia
variants: also

α–thalassemia

\ˌal-fə-ˌtha-lə-ˈsē-mē-ə\ play

Medical Definition of alpha–thalassemia

  1. :  thalassemia in which the hemoglobin chains designated alpha are affected The severity of alpha-thalassemia is directly related to the number of defects occurring in the four genes controlling synthesis of the alpha hemoglobin chain. Defects in one or two of the genes causes a condition that is asymptomatic or marked by mild anemia. Defects in three of the genes cause a condition marked by hemolytic anemia and enlargement of the spleen. Defects in all four genes is fatal and results in a fetus that is stillborn or critically ill with hydrops fetalis. —compare beta-thalassemia


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