Medical Dictionary


noun al·pha–sy·nu·clein
variants: or


\ˌal-fə-si-ˈn(y)ü-klē-ən\ play

Medical Definition of alpha–synuclein

  1. :  a protein that is found primarily in neurons and accumulates to form Lewy bodies in people affected with Parkinson's disease and some forms of dementia … the pathogenesis of Parkinson's disease involves the abnormal folding, aggregation, and deposition of α-synuclein as key steps in mediating neuronal dysfunction and degeneration.—Mel B. Feany, The New England Journal of Medicine, 4 Nov. 2004 Mutations in the gene encoding alpha-synuclein have been linked to a rare, inherited form of Parkinson's disease.

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to cast off or become cast off

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