alpha-synuclein

noun
al·​pha-sy·​nu·​clein
variants: or α-synuclein \ ˌal-​fə-​si-​ˈn(y)ü-​klē-​ən How to pronounce alpha-synuclein (audio) \

Medical Definition of alpha-synuclein

: a protein that is found primarily in neurons and accumulates to form Lewy bodies in people affected with Parkinson's disease and some forms of dementia … the pathogenesis of Parkinson's disease involves the abnormal folding, aggregation, and deposition of α-synuclein as key steps in mediating neuronal dysfunction and degeneration.— Mel B. Feany, The New England Journal of Medicine, 4 Nov. 2004

Note: Mutations in the gene encoding alpha-synuclein have been linked to a rare, inherited form of Parkinson's disease.

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Cite this Entry

“Alpha-synuclein.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/alpha-synuclein. Accessed 8 Dec. 2021.

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