1
: of superior grade or quality
high-grade bonds
2
a
: being near the upper or most favorable extreme of a specified range
b
: medically serious or life-threatening
a high-grade tumor
Examples of high-grade in a Sentence
Recent Examples on the Web
However, if the same high-grade cancer has already spread widely (Stage 4), five-year relative survival drops significantly, to around 38%.
—
Jason P. Joseph, The Conversation, 21 May 2025
Pathologists measure the two cell areas that make up the majority of the cancer then add the scores together to come up with the Gleason score, which ranges from 6, a low-grade cancer, to 10, a high-grade cancer, according to the Cleveland Clinic.
—Sara Dorn, Forbes.com, 20 May 2025
Both Greig and Kelly are high-grade NHL pests with some scoring touch who kill penalties and aren’t afraid to throw their bodies around despite not being huge.
—Max Bultman, New York Times, 19 May 2025
Gleason score of 8 to 10: Cancer is high-grade and may need more aggressive treatment.
—Angelica Stabile, FOXNews.com, 19 May 2025
See All Example Sentences for high-grade
Examples are automatically compiled from online sources to
show current usage.
Read More
Opinions expressed in the examples do not represent those of Merriam-Webster or its editors.
Send us feedback.
Jason P. Joseph, The Conversation, 21 May 2025
Pathologists measure the two cell areas that make up the majority of the cancer then add the scores together to come up with the Gleason score, which ranges from 6, a low-grade cancer, to 10, a high-grade cancer, according to the Cleveland Clinic.
—Sara Dorn, Forbes.com, 20 May 2025
Both Greig and Kelly are high-grade NHL pests with some scoring touch who kill penalties and aren’t afraid to throw their bodies around despite not being huge.
—Max Bultman, New York Times, 19 May 2025
Gleason score of 8 to 10: Cancer is high-grade and may need more aggressive treatment.
—Angelica Stabile, FOXNews.com, 19 May 2025
See All Example Sentences for high-grade
Cite this Entry
“High-grade.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/high-grade. Accessed 29 May. 2025.
Copy CitationLove words? Need even more definitions?
Merriam-Webster unabridged
Share