complementation

noun

com·​ple·​men·​ta·​tion ˌkäm-plə-(ˌ)men-ˈtā-shən How to pronounce complementation (audio)
-mən-
1
: the operation of determining the complement of a mathematical set
2
: production of normal phenotype in an individual heterozygous for two closely related mutations with one on each homologous chromosome and at a slightly different position

Examples of complementation in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Interspecies blastocyst complementation is a method that could help create human organs in animals. Study Summaries, Scientific American, 17 May 2023 Though the papers overlap to a great extent, there are subtle differences which result in complementation. Razib Khan, Discover Magazine, 9 July 2011

Word History

First Known Use

1942, in the meaning defined at sense 1

Time Traveler
The first known use of complementation was in 1942

Cite this Entry

“Complementation.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/complementation. Accessed 7 Sep. 2025.

Medical Definition

complementation

noun
com·​ple·​men·​ta·​tion ˌkäm-plə-(ˌ)men-ˈtā-shən, -mən- How to pronounce complementation (audio)
1
: the formation of neutral colors from complementary colors
2
: production of normal phenotype in an individual heterozygous for two closely related mutations with one on each homologous chromosome and at a slightly different position
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