Definition of complement fixation
: the process of binding serum complement to the product formed by the union of an antibody and the antigen for which it is specific that occurs when complement is added to a suitable mixture of such an antibody and antigen and that is the basis of some tests to detect the presence of specific antibodies or antigens
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Merriam-Webster unabridged
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Time Traveler for complement fixation
The first known use of complement fixation was in 1906
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