bisphosphonate

noun
bis·phos·pho·nate | \ˌbis-ˈfäs-fə-ˌnāt \

Definition of bisphosphonate 

: any of a group of drugs that slow the breakdown of bone by osteoclasts

Examples of bisphosphonate in a Sentence

Recent Examples on the Web

Moreover, patients who take them are usually switched over to bisphosphonates after 18 to 24 months to maintain bone density. Scientific American, "Readers Respond to the March 2018 Issue," 13 Mar. 2018 Some work by a different mechanism than the bisphosphonates and have a different profile of side effects. Scientific American, "Readers Respond to the March 2018 Issue," 13 Mar. 2018 Fosamax was the first of several bisphosphonate drugs that work by slowing the turnover of bone cells. Claudia Wallis, Scientific American, "Osteoporosis: An Avoidable Crisis," 13 Mar. 2018 Use of oral bisphosphonates fell by 50 percent between 2008 and 2012. Claudia Wallis, Scientific American, "Osteoporosis: An Avoidable Crisis," 13 Mar. 2018 Then in the early 2000s, alarming news reports began to appear linking extended use of bisphosphonates to two uncommon bone problems: a very rare fracture of the femur and an even rarer condition called osteonecrosis of the jaw. Jane E. Brody, New York Times, "A Perfect Storm for Broken Bones," 12 Feb. 2018 High doses from supplements may have unpleasant side effects, such as diarrhea, nausea and abdominal cramps, and may prevent some drugs (such as certain antibiotics and bisphosphonates) from doing their jobs. Consumer Reports, Washington Post, "Magnesium is essential to your health, but many people don’t get enough of it," 10 June 2017 Bisphosphonates include Fosomax, Reclast and Zometa to name a few and denosumab is sold under the brand names Prolia and Xgeva. Susan Scutti, CNN, "Experts streamline guidelines for treating osteoporosis," 8 May 2017 The new advisory uses fresh data to guide doctors to prescribe bisphosphonates or denosumab for five years. Susan Scutti, CNN, "Experts streamline guidelines for treating osteoporosis," 8 May 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'bisphosphonate.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

See More

First Known Use of bisphosphonate

1974, in the meaning defined above

History and Etymology for bisphosphonate

bis + phosphonic acid (an acid obtained from phosphine) + -ate entry 1

Keep scrolling for more

Learn More about bisphosphonate

Share bisphosphonate

Statistics for bisphosphonate

Look-up Popularity

Time Traveler for bisphosphonate

The first known use of bisphosphonate was in 1974

See more words from the same year

Keep scrolling for more

More Definitions for bisphosphonate

bisphosphonate

noun
bis·phos·pho·nate | \ˌbis-ˈfäs-fə-ˌnāt\

Medical Definition of bisphosphonate 

: any of a group of drugs (such as alendronate or etidronate) that slow the breakdown of bone by osteoclasts … among the pharmacological approaches for treating osteoporosis, use of bisphosphonates increases bone mineral density and reduces the risk of vertebral fractures.— Charles Marwick, The Journal of the American Medical Association, 26 Apr. 2000

called also diphosphonate

Note: Bisphonates

are analogs of pyrophosphate and contain two phosphate groups attached to a central carbon atom that replaces the oxygen atom in pyrophosphate.

Comments on bisphosphonate

What made you want to look up bisphosphonate? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

a generally accepted meaning of a word

Get Word of the Day daily email!

Test Your Vocabulary

Great Scrabble Words—A Quiz

  • scrabble-tiles-that-read-scrabble-quiz
  • Which of the following Q-without-U words means the number five in cards or dice?
Name That Thing

Test your visual vocabulary with our 10-question challenge!

TAKE THE QUIZ
Dictionary Devil

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!