Definition of bisphosphonate
: any of a group of drugs that slow the breakdown of bone by osteoclasts
Recent Examples of bisphosphonate from the Web
High doses from supplements may have unpleasant side effects, such as diarrhea, nausea and abdominal cramps, and may prevent some drugs (such as certain antibiotics and bisphosphonates) from doing their jobs.
The new advisory uses fresh data to guide doctors to prescribe bisphosphonates or denosumab for five years.
Bisphosphonates include Fosomax, Reclast and Zometa to name a few and denosumab is sold under the brand names Prolia and Xgeva.
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Origin and Etymology of bisphosphonate
bis + phosphonic acid (an acid obtained from phosphine) + 1-ate
First Known Use: 1974See Words from the same year
Medical Definition of bisphosphonate
: any of a group of drugs (such as alendronate or etidronate) that slow the breakdown of bone by osteoclasts … among the pharmacological approaches for treating osteoporosis, use of bisphosphonates increases bone mineral density and reduces the risk of vertebral fractures.—Charles Marwick, The Journal of the American Medical Association, 26 Apr. 2000—called also diphosphonate ◆Bisphonates are analogs of pyrophosphate and contain two phosphate groups attached to a central carbon atom that replaces the oxygen atom in pyrophosphate.
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