Definition of bisphosphonate
: any of a group of drugs that slow the breakdown of bone by osteoclasts
Origin and Etymology of bisphosphonate
bis + phosphonic acid (an acid obtained from phosphine) + 1-ate
First Known Use: 1982
Medical Definition of bisphosphonate
: any of a group of drugs (such as alendronate or etidronate) that slow the breakdown of bone by osteoclasts <… among the pharmacological approaches for treating osteoporosis, use of bisphosphonates increases bone mineral density and reduces the risk of vertebral fractures.—Charles Marwick, The Journal of the American Medical Association, 26 Apr. 2000>—called also diphosphonate ◆Bisphonates are analogs of pyrophosphate and contain two phosphate groups attached to a central carbon atom that replaces the oxygen atom in pyrophosphate.
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