Definition of antinuclear
1 : opposing the use or production of nuclear power
2 : tending to react with cell nuclei or their components (such as DNA) antinuclear antibodies
First Known Use of antinuclear
Medical Definition of antinuclear
: being antibodies or autoantibodies that react with components and especially DNA of cell nuclei and that tend to occur frequently in connective tissue diseases (as systemic lupus erythematosus, rheumatoid arthritis, and Sjögrens syndrome)
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