mono·​nu·​cle·​ar ˌmä-nə-ˈnü-klē-ər How to pronounce mononuclear (audio)
-kyə-lər How to pronounce mononuclear (audio)
: having only one nucleus
a mononuclear cell
mononuclear noun

Example Sentences

Recent Examples on the Web To deliver the therapy, clinicians draw a group of cells called bone marrow mononuclear cells from patients’ hips. Andrew Joseph, STAT, 13 Apr. 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'mononuclear.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

Word History


International Scientific Vocabulary

First Known Use

1886, in the meaning defined above

Time Traveler
The first known use of mononuclear was in 1886

Dictionary Entries Near mononuclear

Cite this Entry

“Mononuclear.” Dictionary, Merriam-Webster, Accessed 29 Jan. 2023.

Medical Definition


1 of 2 adjective
mono·​nu·​cle·​ar ˌmän-ō-ˈn(y)ü-klē-ər How to pronounce mononuclear (audio)
: having only one nucleus
a mononuclear cell


2 of 2 noun
: a mononuclear cell
especially : monocyte
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