an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
Recent Examples on the Web
The New York Times News Service Syndicate, San Diego Union-Tribune, 27 Jan. 2026
When Zeko first sought help in 2011, her doctor prescribed the antidepressant bupropion, which Zeko took on and off for several years.
—Cnn.com Wire Service, Mercury News, 15 Jan. 2026
Owen Clarke, Outside, 9 Jan. 2026
Key Takeaways Coffee can interfere with how your body absorbs or reacts to many common medications, including antidepressants, anticoagulants, and thyroid drugs.
—Carrie Madormo, Verywell Health, 7 Jan. 2026
See All Example Sentences for antidepressant
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Adjective
In general, it is estimated that about 1 in 6 people who discontinue their antidepressant experiences adverse symptoms.
—The New York Times News Service Syndicate, San Diego Union-Tribune, 27 Jan. 2026
When Zeko first sought help in 2011, her doctor prescribed the antidepressant bupropion, which Zeko took on and off for several years.
—Cnn.com Wire Service, Mercury News, 15 Jan. 2026
Noun
One spring in particular showed traces of several pharmaceuticals, including an antibiotic, an antifungal, an anticonvulsant, an antidepressant, and a diabetic drug.
—Owen Clarke, Outside, 9 Jan. 2026
Key Takeaways Coffee can interfere with how your body absorbs or reacts to many common medications, including antidepressants, anticoagulants, and thyroid drugs.
—Carrie Madormo, Verywell Health, 7 Jan. 2026
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 2 Feb. 2026.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
