an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
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Gabrielle Rockson, PEOPLE, 23 Sep. 2025
Key Takeaways Lexapro is an antidepressant medication that is also taken to treat anxiety.
—Megan Nunn, Verywell Health, 22 Sep. 2025
Clarissa Brincat, Popular Science, 25 Sep. 2025
On the other hand, the use of antidepressants and of gabapentin has increased.
—Paula Span, Miami Herald, 25 Sep. 2025
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Adjective
The court heard that the use of the antidepressant Nortriptyline contributed to the deaths of the children, according to the BBC.
—Gabrielle Rockson, PEOPLE, 23 Sep. 2025
Key Takeaways Lexapro is an antidepressant medication that is also taken to treat anxiety.
—Megan Nunn, Verywell Health, 22 Sep. 2025
Noun
Additionally, research has shown that a VNS implant significantly improves mood, vitality, and overall well-being in people with depression for whom traditional antidepressants are ineffective.
—Clarissa Brincat, Popular Science, 25 Sep. 2025
On the other hand, the use of antidepressants and of gabapentin has increased.
—Paula Span, Miami Herald, 25 Sep. 2025
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 30 Sep. 2025.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
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