an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
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Angelica Peebles, CNBC, 31 Mar. 2026
This is a common step because some research suggests certain antidepressant medications could blunt psilocybin’s effects.
—Natalia V. Osipova, CNN Money, 28 Mar. 2026
Los Angeles Times, 2 Apr. 2026
Pharmaceuticals in drinking water The presence in drinking water of antidepressants, hormones, antibiotics and other medications from human waste and improper disposal is also being prioritized as a group for the first time, Zeldin said.
—Sandee Lamotte, CNN Money, 2 Apr. 2026
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Adjective
The company’s antidepressant Prozac catapulted Lilly to the top ranks of the pharmaceutical industry after it was approved in 1987.
—Angelica Peebles, CNBC, 31 Mar. 2026
This is a common step because some research suggests certain antidepressant medications could blunt psilocybin’s effects.
—Natalia V. Osipova, CNN Money, 28 Mar. 2026
Noun
The film’s perspective on mental health, including Sam being open about his use of antidepressants, is quietly refreshing.
—Los Angeles Times, 2 Apr. 2026
Pharmaceuticals in drinking water The presence in drinking water of antidepressants, hormones, antibiotics and other medications from human waste and improper disposal is also being prioritized as a group for the first time, Zeldin said.
—Sandee Lamotte, CNN Money, 2 Apr. 2026
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 8 Apr. 2026.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
