an·​ti·​de·​pres·​sant | \ ˌan-tē-di-ˈpre-sᵊnt How to pronounce antidepressant (audio) , ˌan-ˌtī- How to pronounce antidepressant (audio) \

Definition of antidepressant

 (Entry 1 of 2)

: used or tending to relieve or prevent depression antidepressant drugs



Definition of antidepressant (Entry 2 of 2)

Examples of antidepressant in a Sentence

Recent Examples on the Web: Adjective So far, certain probiotics have been shown to reduce stress and anxiety behaviors in rodents, while prebiotics (essentially food for probiotics) may have an antidepressant effect on mice, reversing the impact of chronic stress. Laura Newberry, Los Angeles Times, 13 Sep. 2022 Some adolescents are unable to start DBT without a medication, like an antidepressant or anti-anxiety drug, to calm the brain enough for treatment to take hold. Matt Richtel,, 27 Aug. 2022 To make the whole thing more dubious, numerous other studies on antidepressant efficacy, many with even worse outcomes, have been systematically suppressed by manufacturers. Eleanor Cummins, The New Republic, 10 Aug. 2022 Neither the antidepressant fluvoxamine, often used to treat obsessive-compulsive disorder, nor the gout drug colchicine, was shown to provide benefit to COVID-19 patients. Adrianna Rodriguez, USA TODAY, 16 July 2022 Closer inspection showed that the pills that were in the laxative bottle were actually antidepressant pills, officials said. Jodicee Arianna, The Arizona Republic, 30 June 2022 Since then, ketamine’s antidepressant potential has captivated researchers, pharmaceutical companies and patients alike. Raleigh Mcelvery, Smithsonian Magazine, 24 May 2022 Adults aged 18-39 are suffering the most, and females are twice as likely to experience anxiety as men and twice as likely to be prescribed anti-anxiety or antidepressant medication. Marija Butkovic, Forbes, 11 July 2022 One 13-year-old rising eighth grader in Colorado currently takes the antidepressant Paxil and the stimulant Adderall. New York Times, 9 July 2022 Recent Examples on the Web: Noun Then came the discovery of the first chemical antidepressant, imipramine, in the 1950s. Laura Newberry, Los Angeles Times, 13 Sep. 2022 Led by Robin Carhart-Harris, who now directs the Neuroscape Psychedelics Division at the University of California, San Francisco, the research compared psilocybin with a standard antidepressant. WIRED, 2 Sep. 2022 Late last year, Merryman had sharply reduced his dosage of Cymbalta, an antidepressant, which could have caused his psychotic break, Koshes reported. Paul Duggan, Washington Post, 1 July 2022 In another study, scientists found that even at low levels in the environment, an antidepressant called fluoxetine resulted in starlings feeding less often than usual during their foraging routines that take place at sunrise and sunset. Anuradha Varanasi, Forbes, 24 June 2022 Gil was taking the antidepressant trazodone, medical records show. Kelly Davis, San Diego Union-Tribune, 4 Apr. 2022 Fluvoxamine, an antidepressant pill that is approved in the U.S. for obsessive-compulsive disorder, can tame inflammatory responses, which typically arise in severe COVID-19. Esther Landhuis, Scientific American, 21 Jan. 2022 Her mix of psychotropic pills shifted, expanded: antipsychotics, mood stabilizers, an antidepressant, a benzodiazepine for anxiety, a stimulant for attention deficit. New York Times, 17 May 2022 Long gone are the days when health plans and PBMs had to worry about the launch of a new cholesterol pill or prescription antidepressant that would cost $4 each and be taken by millions of Americans. Bruce Japsen, Forbes, 3 May 2022 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'antidepressant.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of antidepressant


1961, in the meaning defined above


1962, in the meaning defined above

Learn More About antidepressant

Time Traveler for antidepressant

Time Traveler

The first known use of antidepressant was in 1961

See more words from the same year

Dictionary Entries Near antidepressant




See More Nearby Entries 

Statistics for antidepressant

Last Updated

25 Sep 2022

Cite this Entry

“Antidepressant.” Dictionary, Merriam-Webster, Accessed 6 Oct. 2022.

Style: MLA
MLACheck Mark Icon ChicagoCheck Mark Icon APACheck Mark Icon Merriam-WebsterCheck Mark Icon

More Definitions for antidepressant


an·​ti·​de·​pres·​sant | \ ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī- How to pronounce antidepressant (audio) \
variants: also antidepressive \ -​ˈpres-​iv How to pronounce antidepressant (audio) \

Medical Definition of antidepressant

 (Entry 1 of 2)

: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant an antidepressant drug antidepressant treatment


variants: also antidepressive

Medical Definition of antidepressant (Entry 2 of 2)

: a drug used to treat psychological depression : an antidepressant drug The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.— John Mann, The New England Journal of Medicine

called also energizer, psychic energizer, psychostimulant

— see tricyclic antidepressant


Test Your Vocabulary

The Great British Vocabulary Quiz

  • union jack speech bubble
  • Named after Sir Robert Peel, what are British police called?
Spell It

Can you spell these 10 commonly misspelled words?

Universal Daily Crossword

A daily challenge for crossword fanatics.

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!