antagonistic

adjective

an·​tag·​o·​nis·​tic (ˌ)an-ˌta-gə-ˈni-stik 

: showing dislike or opposition : marked by or resulting from antagonism

an antagonistic relationship

factions antagonistic to one another

antagonistically

(ˌ)an-ˌta-gə-ˈni-sti-k(ə-)lē 

adverb

Synonyms of antagonistic

• hostile
• negative

Examples of antagonistic in a Sentence

They found it impossible to deal with such antagonistic groups.

countries that have been antagonistic towards each other for centuries

Recent Examples on the Web

Ultimately, even when she’s supposed to play the most antagonistic female archetype, Darlene is simply too much of a mood and a vibe, and her fundamentally anti-Karen nature is good for TV but bad for the judging criteria in this challenge. —Rebecca Alter, Vulture, 28 Mar. 2026

Every show’s got their characters that are sort of the odd man out or the antagonistic energies, and that’s who Rocky played. —Chris Willman, Variety, 25 Mar. 2026

After Kennedy, Prasad is the senior official most antagonistic toward pharmaceutical companies. —Tom Bartlett, The Atlantic, 25 Mar. 2026

In a separate text to Tharpe, Jay linked antagonistic stan culture to the ascension of the far-right. —Jazz Monroe, Pitchfork, 24 Mar. 2026

Word History

Etymology

see antagonize

First Known Use

circa 1637, in the meaning defined above

Rhymes for antagonistic

• anachronistic
• animalistic
• antiphlogistic
• behavioristic
• cannibalistic
• capitalistic
• characteristic
• collectivistic
• deterministic
• ethnolinguistic
• expressionistic
• idealistic

Kids Definition

antagonistic

adjective

an·​tag·​o·​nis·​tic (ˌ)an-ˌtag-ə-ˈnis-tik 

: showing antagonism

antagonistically

-ti-k(ə-)lē 

adverb

Medical Definition

antagonistic

adjective

an·​tag·​o·​nis·​tic (ˌ)an-ˌtag-ə-ˈnis-tik 

1

: characterized by or resulting from antagonism

antagonistic antibiotics

2

: relating to or being muscles that are antagonists

skeletal muscles arranged in antagonistic pairs

antagonistically

-ti-k(ə-)lē 

adverb