cortisol

noun

cor·​ti·​sol ˈkȯr-tə-ˌsȯl 

-ˌzȯl, 

-ˌsōl, 

-ˌzōl

: a glucocorticoid C₂₁H₃₀O₅ produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

Examples of cortisol in a Sentence

Recent Examples on the Web

Her team's research on cortisol and brain function has revolutionized our understanding and treatment of PTSD worldwide. —Big Think, 3 Apr. 2026

Tests worth requesting include a thyroid panel, FSH, estradiol, cortisol and iron levels. —Allison Palmer, Kansas City Star, 1 Apr. 2026

The Symptom Picture to Look For A rounder face on its own is not enough to point to cortisol. —Allison Palmer, Sacbee.com, 1 Apr. 2026

Temporary morning puffiness or a rounder face with no other symptoms is far less likely to be cortisol-related. —Allison Palmer, Fort Worth Star-Telegram, 1 Apr. 2026

Word History

Etymology

cortisone + -ol entry 1

First Known Use

1951, in the meaning defined above

Rhymes for cortisol

• aerosol
• alcohol
• arbitral
• basketball
• butanol
• cannonball
• carbinol
• catarrhal
• ethanol
• fireball
• gasohol
• guaiacol

Medical Definition

cortisol

noun

cor·​ti·​sol ˈkȯrt-ə-ˌsȯl, -ˌzȯl, -ˌsōl, -ˌzōl 

: a glucocorticoid C₂₁H₃₀O₅ produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone