upstream

adverb or adjective up·stream \ ˈəp-ˈstrēm \

Definition of upstream

1 :in the direction opposite to the flow of a stream
2 :in or to a position within the production stream closer to manufacturing processes
  • make most of its money upstream, selling cheap crude … to refineries
  • —John Quirt

First Known Use of upstream

1681


UPSTREAM Defined for English Language Learners

upstream

adverb

Definition of upstream for English Language Learners

  • : in the direction opposite to the flow in a stream, river, etc. : toward the source of a stream, river, etc.


UPSTREAM Defined for Kids

upstream

adverb up·stream \ ˈəp-ˈstrēm \

Definition of upstream for Students

:at or toward the beginning of a stream
  • She rowed upstream.

Medical Dictionary

upstream

adverb or adjective up·stream \ ˈəp-ˈstrēm \

medical Definition of upstream

1 :in a direction along a molecule of DNA or RNA opposite to that in which transcription and translation take place and toward the end having a phosphate group attached to the position labeled 5′ in the terminal nucleotide
  • … stretches of DNA upstream of genes—are known as promoters.
  • —Matt RidleyTime2 June 2003
— compare downstream 1
2 :toward the beginning of series of cellular processes :preceding a linked molecular event occurring in a sequence
  • It's equally important to focus on additional mechanisms that are upstream of amyloid formation and mechanisms downstream that are involved in the actual degenerative processes within neurons.
  • —Marc Tessier-Lavignequoted in Science17 Sept. 2010


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