upstream

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adverb or adjective up·stream \ˈəp-ˈstrēm\

Definition of upstream

  1. 1 :  in the direction opposite to the flow of a stream

  2. 2 :  in or to a position within the production stream closer to manufacturing processes make most of its money upstream, selling cheap crude … to refineries — John Quirt

First Known Use of upstream

1681


UPSTREAM Defined for English Language Learners

upstream

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adverb

Definition of upstream for English Language Learners

  • : in the direction opposite to the flow in a stream, river, etc. : toward the source of a stream, river, etc.


UPSTREAM Defined for Kids

upstream

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adverb up·stream \ˈəp-ˈstrēm\

Definition of upstream for Students

  1. :  at or toward the beginning of a stream She rowed upstream.


Medical Dictionary

upstream

play
adverb or adjective up·stream \ˈəp-ˈstrēm\

Medical Definition of upstream

  1. 1:  in a direction along a molecule of DNA or RNA opposite to that in which transcription and translation take place and toward the end having a phosphate group attached to the position labeled 5′ in the terminal nucleotide … stretches of DNA upstream of genes—are known as promoters.—Matt Ridley, Time, 2 June 2003—compare downstream 1

  2. 2:  toward the beginning of series of cellular processes :  preceding a linked molecular event occurring in a sequence It's equally important to focus on additional mechanisms that are upstream of amyloid formation and mechanisms downstream that are involved in the actual degenerative processes within neurons.—Marc Tessier-Lavigne, quoted in Science, 17 Sept. 2010



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