: in the direction of or nearer to the mouth of a stream
- located two miles downstream
: in or toward the latter stages of a usually industrial process or the stages (such as marketing) after manufacture
- improving profits downstream
: toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence
- But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.
- —Marcia Barinaga