First Known Use of downstream
Financial Definition of DOWNSTREAM
What It Is
Downstream refers to the benefits (or costs) that will ultimately result from decisions made today.
How It Works
In finance, a series of investments might be made with the anticipation that at a point in time in the future these efforts will yield a series of returns. These returns occur after the initial investments. As a result, they are referred to as downstream benefits. Similarly, investments can have downstream "costs" as well. The expectation is that the downstream benefits will outweigh the downstream costs.
At the same time, because the future is hard to predict, downstream effects are often unanticipated, setting off unintended costs and consequences.
Why It Matters
It is important to consider the "downstream" effects of an investment decision since it will impact ones future economic performance.
DOWNSTREAM Defined for English Language Learners
Definition of downstream for English Language Learners
: in the direction in which a stream, river, etc., flows
DOWNSTREAM Defined for Kids
Definition of downstream for Students
- paddling downstream
medical Definition of downstream
- a nucleotide sequence located downstream from the regulatory gene
- effects on the expression of downstream genes
- But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.
- —Marcia Barinaga, Science, 7 Nov. 1997
- The tyrosine kinase activity of phosphorylated EGFR [epidermal growth factor receptor] in cancer cells results in the phosphorylation of downstream proteins that incite cell proliferation, invasion, metastasis, and inhibition of apoptosis.
- —Jonathan E. Dowell and John D. Minna, The New England Journal of Medicine, 24 Feb. 2005
Seen and Heard
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