downstream

adverb or adjective

down·​stream ˈdau̇n-ˈstrēm How to pronounce downstream (audio)
1
: in the direction of or nearer to the mouth of a stream
floating downstream
located two miles downstream
2
: in or toward the latter stages of a usually industrial process or the stages (such as marketing) after manufacture
improving profits downstream
downstream products
3
biochemistry : toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence
But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.Marcia Barinaga

Examples of downstream in a Sentence

Recent Examples on the Web An area several miles downstream of Gore’s Cherry Hill site made the list. Christine Condon, Baltimore Sun, 15 Feb. 2024 Still considered the bloodiest single-day conflict in American history, the Battle of Antietam was fought just miles downstream of the county park near the town of Sharpsburg. Bob McNally, Outdoor Life, 14 Feb. 2024 Advertisement Had there been no cleanout, the sediment would’ve been so high by now, the dam’s release valves would’ve clogged, and officials would’ve been helpless as floodwaters rushed over the spillway, resulting in an uncontrolled flow downstream along the Arroyo Seco. Rong-Gong Lin Ii, Los Angeles Times, 11 Feb. 2024 Today the 15-mile greenway is a hub of activity, including fly-fishers casting in shallow pools and college kids floating downstream in inner tubes. Robert Annis, Travel + Leisure, 2 Feb. 2024 As a result, economic activity will tend to shift downstream in the GenAI value chain, drawing in an expanding set of players—those with the best data in a specific domain—to either partner with tech firms or directly fine-tune models themselves. François Candelon, Fortune, 2 Feb. 2024 Western tanagers escort rafters downstream — yellow flashes flittering from juniper to juniper. Pete Zimowsky, Idaho Statesman, 31 Jan. 2024 Additional barriers could include electric currents, sound and other disturbances to turn the fish back downstream. John Myers, Twin Cities, 20 Jan. 2024 National Park Service After removal of the Glines Canyon Dam, the former bed of Lake Mills now allows the Elwha to snake its way downstream. Alka Tripathy-Lang, Ars Technica, 11 Jan. 2024 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'downstream.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1591, in the meaning defined at sense 1

Time Traveler
The first known use of downstream was in 1591

Dictionary Entries Near downstream

Cite this Entry

“Downstream.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/downstream. Accessed 24 Feb. 2024.

Kids Definition

downstream

adverb or adjective
down·​stream ˈdau̇n-ˈstrēm How to pronounce downstream (audio)
: in the direction a stream is flowing

Medical Definition

downstream

adverb or adjective
down·​stream ˌdau̇n-ˈstrēm How to pronounce downstream (audio)
1
: in the same direction along a molecule of DNA or RNA as that in which transcription and translation take place and toward the end having a hydroxyl group attached to the position labeled 3′ in the terminal nucleotide
a nucleotide sequence located downstream from the regulatory gene
effects on the expression of downstream genes
compare upstream sense 1
2
: toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence
But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.Marcia Barinaga, Science
The tyrosine kinase activity of phosphorylated EGFR [epidermal growth factor receptor] in cancer cells results in the phosphorylation of downstream proteins that incite cell proliferation, invasion, metastasis, and inhibition of apoptosis.Jonathan E. Dowell and John D. Minna, The New England Journal of Medicine

More from Merriam-Webster on downstream

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