downstream

adverb or adjective
down·​stream | \ ˈdau̇n-ˈstrēm How to pronounce downstream (audio) \

Definition of downstream

1 : in the direction of or nearer to the mouth of a stream floating downstream located two miles downstream
2 : in or toward the latter stages of a usually industrial process or the stages (such as marketing) after manufacture improving profits downstream downstream products
3 biochemistry : toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.— Marcia Barinaga

Examples of downstream in a Sentence

Recent Examples on the Web The weather service said in a tweet there is a possibility of flash floods downstream of fire burn scars in southern Gila and eastern Maricopa counties. Chloe Jones, The Arizona Republic, "Are temps in the 70s really coming to Phoenix next week? Here's what we know," 23 Oct. 2020 The effects are traveling downstream from the high country to the reservoirs that supply water for farmlands and millions of people. Ian James, AZCentral.com, "Climate's toll on the Colorado River: 'We can weather maybe a couple of years'," 1 Jan. 2021 Vacuum leaks happen downstream of the mass airflow (commonly abbreviated as MAF) sensor, which is the device that measures the incoming air. Mike Allen, Popular Mechanics, "How to Find a Vacuum Leak," 2 Oct. 2020 The small lake was formed by a dam just downstream from the spring at what's now Mammoth Spring State Park. Rex Nelson, Arkansas Online, "Spring River country," 29 Nov. 2020 The Riverkeeper vessel cut away from the dam and motored downstream under a confetti of white pelicans and bald eagles, and between shorelines of heavy tree canopy. Kevin Spear, orlandosentinel.com, "Crippled Apalachicola River leaves wetland forests in peril, famous oysters extinct | Part 2 of Special Series," 10 Dec. 2020 The corps would dig an 8-foot deep trench in the river bottom just downstream of the island to provide an overwintering and spawning spot for fish. Greg Stanley, Star Tribune, "To protect Mississippi River dam, Army Corps may build an island near Hastings," 16 Nov. 2020 Wildlife agencies are funding the pilot program to cull the brown trout population in the Colorado River, in the hopes of keeping the predacious trout from moving downstream and endangering native fish, like the humpback chub. Anton L. Delgado, The Arizona Republic, "To protect native fish, agencies put a bounty on brown trout in the Colorado River," 20 Nov. 2020 After heavy rainstorms, the collection traps that had been placed on a river’s shore could be washed downstream. Theresa Machemer, Smithsonian Magazine, "Two New Species of Semi-Aquatic Mice Identified in East African Rainforests," 14 Oct. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'downstream.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of downstream

1591, in the meaning defined at sense 1

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Time Traveler for downstream

Time Traveler

The first known use of downstream was in 1591

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Statistics for downstream

Last Updated

7 Mar 2021

Cite this Entry

“Downstream.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/downstream. Accessed 7 Mar. 2021.

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More Definitions for downstream

downstream

adverb

English Language Learners Definition of downstream

: in the direction in which a stream, river, etc., flows

downstream

adverb
down·​stream | \ ˈdau̇n-ˈstrēm How to pronounce downstream (audio) \

Kids Definition of downstream

: in the direction a stream is flowing paddling downstream

downstream

adverb or adjective
down·​stream | \ ˌdau̇n-ˈstrēm How to pronounce downstream (audio) \

Medical Definition of downstream

1 : in the same direction along a molecule of DNA or RNA as that in which transcription and translation take place and toward the end having a hydroxyl group attached to the position labeled 3′ in the terminal nucleotide a nucleotide sequence located downstream from the regulatory gene effects on the expression of downstream genes — compare upstream sense 1
2 : toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.— Marcia Barinaga, Science, 7 Nov. 1997 The tyrosine kinase activity of phosphorylated EGFR [epidermal growth factor receptor] in cancer cells results in the phosphorylation of downstream proteins that incite cell proliferation, invasion, metastasis, and inhibition of apoptosis.— Jonathan E. Dowell and John D. Minna, The New England Journal of Medicine, 24 Feb. 2005

More from Merriam-Webster on downstream

Nglish: Translation of downstream for Spanish Speakers

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