Definition of sildenafil
: a drug that is used in the form of its citrate C22H30N6O4S·C6H8O7 to treat erectile dysfunction in males, that by suppressing a phosphodiesterase enzyme also suppresses the enzyme's inhibitory effect on the hormone cyclic GMP, and that enables the cyclic GMP produced during sexual arousal to initiate the muscular and vascular changes which produce an erection ◆Sildenafil is marketed under the trademarks Revatio and Viagra .
Origin and Etymology of sildenafil
perhaps by alteration and recombination of letters from sulfonyl, phenyl, and pyrimidine
First Known Use: 1995
Medical Definition of sildenafil
: a drug that is used in the form of its citrate C22H30N6O4S·C6H8O7 chiefly to treat erectile dysfunction in males and hypertension of the lungs ◆Sildenafil inhibits a phosphodiesterase enzyme that degrades cyclic GMP. Higher levels of cyclic GMP in the body promote relaxation of smooth muscle, which allows for increased blood flow to the lungs to lower blood pressure and to the corpus cavernosum to produce an erection during sexual arousal. Sildenafil is marketed under the trademark Viagra to treat erectile dysfunction and under the trademark Revatio to treat pulmonary arterial hypertension.
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