sildenafil

noun
sil·​den·​a·​fil | \ sil-ˈde-nə-ˌfil How to pronounce sildenafil (audio) \

Definition of sildenafil

: a drug that is used in the form of its citrate C22H30N6O4S·C6H8O7 to treat erectile dysfunction in males, that by suppressing a phosphodiesterase enzyme also suppresses the enzyme's inhibitory effect on the hormone cyclic GMP, and that enables the cyclic GMP produced during sexual arousal to initiate the muscular and vascular changes which produce an erection

Note: Sildenafil is marketed under the trademarks Revatio and Viagra.

Examples of sildenafil in a Sentence

Recent Examples on the Web The maximum dose of sildenafil (Viagra) is 100 milligrams. Dr. Keith Roach, oregonlive, 7 Apr. 2021 According to a new recall bulletin posted by the FDA, the supplement was found to contain sildenafil and tadalafil. Mike Wehner, BGR, 26 Mar. 2021 AvKARE, a healthcare firm based out of Pulaski, Tennessee, on Tuesday announced a recall of its generic sildenafil, the active ingredient in Viagra, and trazodone, an antidepressant and sleep aid. Joshua Bote, USA TODAY, 10 Dec. 2020 Unintentional consumption of sildenafil can pose serious health risks for those with underlying health issues, such as lowering blood pressure to dangerous levels for those taking prescriptions containing nitrates. Jen Christensen, CNN, 10 Dec. 2020 Though the recall itself is relatively small — a single lot of each medication, affecting only 100 bottles of sildenafil and 1,000 bottles of trazodone — patients who wrongly take either medication could face severe health risks. Joshua Bote, USA TODAY, 10 Dec. 2020 This discovery led to the development and marketing of sildenafil, trade name Viagra, which works by enhancing the action of NO. The Conversation, oregonlive, 19 June 2020 This discovery led to the development and marketing of sildenafil, trade name Viagra, which works by enhancing the action of NO. The Conversation, 19 June 2020 Like nitric oxide, Viagra, known generically as sildenafil, dilates blood vessels. Los Angeles Times, 5 Apr. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'sildenafil.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of sildenafil

1995, in the meaning defined above

History and Etymology for sildenafil

perhaps by alteration and recombination of letters from sulfonyl, phenyl, and pyrimidine

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Time Traveler for sildenafil

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The first known use of sildenafil was in 1995

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Dictionary Entries Near sildenafil

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sile

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Cite this Entry

“Sildenafil.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/sildenafil. Accessed 28 Nov. 2021.

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More Definitions for sildenafil

sildenafil

noun
sil·​den·​a·​fil | \ sil-ˈden-ə-ˌfil How to pronounce sildenafil (audio) \

Medical Definition of sildenafil

: a drug that is used in the form of its citrate C22H30N6O4S·C6H8O7 chiefly to treat erectile dysfunction in males and hypertension of the lungs

Note: Sildenafil inhibits a phosphodiesterase enzyme that degrades cyclic GMP. Higher levels of cyclic GMP in the body promote relaxation of smooth muscle, which allows for increased blood flow to the lungs to lower blood pressure and to the corpus cavernosum to produce an erection during sexual arousal. Sildenafil is marketed under the trademark Viagra to treat erectile dysfunction and under the trademark Revatio to treat pulmonary arterial hypertension.

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