sildenafil

noun
sil·​den·​a·​fil | \ sil-ˈde-nə-ˌfil How to pronounce sildenafil (audio) \

Definition of sildenafil

: a drug that is used in the form of its citrate C22H30N6O4S·C6H8O7 to treat erectile dysfunction in males, that by suppressing a phosphodiesterase enzyme also suppresses the enzyme's inhibitory effect on the hormone cyclic GMP, and that enables the cyclic GMP produced during sexual arousal to initiate the muscular and vascular changes which produce an erection

Note: Sildenafil is marketed under the trademarks Revatio and Viagra.

Examples of sildenafil in a Sentence

Recent Examples on the Web This discovery led to the development and marketing of sildenafil, trade name Viagra, which works by enhancing the action of NO. The Conversation, oregonlive, "The science behind why this is the safest way to breathe to avoid coronavirus," 19 June 2020 This discovery led to the development and marketing of sildenafil, trade name Viagra, which works by enhancing the action of NO. The Conversation, "The right way to breathe during the coronavirus pandemic," 19 June 2020 Like nitric oxide, Viagra, known generically as sildenafil, dilates blood vessels. Los Angeles Times, "How a discovery that brought us Viagra could help those battling the coronavirus," 5 Apr. 2020 The supplement contains sildenafil, the active ingredient in Viagra and other erectile dysfunction medications, according to the FDA. Kristin Lam, USA TODAY, "Big Penis supplement contains hidden ingredient, FDA warns," 18 July 2019 Tests found that Landers' drug contained sildenafil, the active ingredient in the erectile dysfunction drug Viagra, which is banned in horse racing. Kevin Krause, Dallas News, "Pharmacy owner whose drugs led to doped racehorses admits to peddling unsafe equine drugs," 5 July 2019 Medical researchers have reported that sildenafil can boost performance in racehorses, which are prone to lung bleeding and edema after races. Kevin Krause, Dallas News, "Pharmacy owner whose drugs led to doped racehorses admits to peddling unsafe equine drugs," 5 July 2019 Earlier this month, Facebook removed three Hims ads for sildenafil that had been flagged by WIRED; a Facebook spokesperson said the ads violated Facebook policies. Nicholas Thompson, WIRED, "Health Brands Hims and Hers Flout Facebook’s Rules on Drug Ads," 1 July 2019 Trial Cut Short After Baby Deaths A trial involving sildenafil, better known as Viagra, was halted last July after the deaths of 11 babies. Mark Barna, Discover Magazine, "State of Science: A Tragic Drug Trial, Questioning Chemo and Immune Improvements," 1 Jan. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'sildenafil.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of sildenafil

1995, in the meaning defined above

History and Etymology for sildenafil

perhaps by alteration and recombination of letters from sulfonyl, phenyl, and pyrimidine

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Time Traveler for sildenafil

Time Traveler

The first known use of sildenafil was in 1995

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Cite this Entry

“Sildenafil.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/sildenafil. Accessed 29 Nov. 2020.

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More Definitions for sildenafil

sildenafil

noun
sil·​den·​a·​fil | \ sil-ˈden-ə-ˌfil How to pronounce sildenafil (audio) \

Medical Definition of sildenafil

: a drug that is used in the form of its citrate C22H30N6O4S·C6H8O7 chiefly to treat erectile dysfunction in males and hypertension of the lungs

Note: Sildenafil inhibits a phosphodiesterase enzyme that degrades cyclic GMP. Higher levels of cyclic GMP in the body promote relaxation of smooth muscle, which allows for increased blood flow to the lungs to lower blood pressure and to the corpus cavernosum to produce an erection during sexual arousal. Sildenafil is marketed under the trademark Viagra to treat erectile dysfunction and under the trademark Revatio to treat pulmonary arterial hypertension.

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