sildenafil

noun
sil·den·a·fil | \sil-ˈde-nə-ˌfil \

Definition of sildenafil 

: a drug that is used in the form of its citrate C22H30N6O4S·C6H8O7 to treat erectile dysfunction in males, that by suppressing a phosphodiesterase enzyme also suppresses the enzyme's inhibitory effect on the hormone cyclic GMP, and that enables the cyclic GMP produced during sexual arousal to initiate the muscular and vascular changes which produce an erection

Note: Sildenafil is marketed under the trademarks Revatio and Viagra.

Examples of sildenafil in a Sentence

Recent Examples on the Web

Pfizer was developing a chemical compound called sildenafil citrate for high blood pressure. Michael S. Rosenwald, chicagotribune.com, "The Viagra jackpot: A history of the little blue pill at 20," 28 Mar. 2018 Pfizer was developing a chemical compound called sildenafil citrate for high blood pressure. The Washington Post, NOLA.com, "The Viagra jackpot: A history of the little blue pill at 20," 28 Mar. 2018 Pfizer was developing a chemical compound called sildenafil citrate for high blood pressure. Michael S. Rosenwald, chicagotribune.com, "The Viagra jackpot: A history of the little blue pill at 20," 28 Mar. 2018 Pfizer was developing a chemical compound called sildenafil citrate for high blood pressure. The Washington Post, NOLA.com, "The Viagra jackpot: A history of the little blue pill at 20," 28 Mar. 2018 Pfizer was developing a chemical compound called sildenafil citrate for high blood pressure. Michael S. Rosenwald, chicagotribune.com, "The Viagra jackpot: A history of the little blue pill at 20," 28 Mar. 2018 Pfizer was developing a chemical compound called sildenafil citrate for high blood pressure. The Washington Post, NOLA.com, "The Viagra jackpot: A history of the little blue pill at 20," 28 Mar. 2018 Pfizer was developing a chemical compound called sildenafil citrate for high blood pressure. Michael S. Rosenwald, chicagotribune.com, "The Viagra jackpot: A history of the little blue pill at 20," 28 Mar. 2018 Pfizer was developing a chemical compound called sildenafil citrate for high blood pressure. The Washington Post, NOLA.com, "The Viagra jackpot: A history of the little blue pill at 20," 28 Mar. 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'sildenafil.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of sildenafil

1995, in the meaning defined above

History and Etymology for sildenafil

perhaps by alteration and recombination of letters from sulfonyl, phenyl, and pyrimidine

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Dictionary Entries near sildenafil

Silastic

silcrete

sild

sildenafil

sile

silen

silence

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Time Traveler for sildenafil

The first known use of sildenafil was in 1995

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More Definitions for sildenafil

sildenafil

noun
sil·den·a·fil | \sil-ˈden-ə-ˌfil \

Medical Definition of sildenafil 

: a drug that is used in the form of its citrate C22H30N6O4S·C6H8O7 chiefly to treat erectile dysfunction in males and hypertension of the lungs

Note: Sildenafil inhibits a phosphodiesterase enzyme that degrades cyclic GMP. Higher levels of cyclic GMP in the body promote relaxation of smooth muscle, which allows for increased blood flow to the lungs to lower blood pressure and to the corpus cavernosum to produce an erection during sexual arousal. Sildenafil is marketed under the trademark Viagra to treat erectile dysfunction and under the trademark Revatio to treat pulmonary arterial hypertension.

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