scle·​ro·​sis | \ sklə-ˈrō-səs How to pronounce sclerosis (audio) \

Definition of sclerosis

1 : pathological hardening of tissue especially from overgrowth of fibrous tissue or increase in interstitial tissue also : a disease characterized by sclerosis
2 : an inability or reluctance to adapt or compromise political sclerosis

Examples of sclerosis in a Sentence

Recent Examples on the Web European countries have strived for years to shed sclerosis from government-centrist policies. Phillip Molnar, San Diego Union-Tribune, 7 May 2021 Multiple sclerosis and other autoimmune diseases, for example, can be treated with a multitude of drugs, each targeting a slightly different branch of the immune system. Katherine J. Wu, The Atlantic, 15 Apr. 2021 Those diagnosed with Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Bone marrow transplant recipients. Jessie Balmert, The Enquirer, 22 Mar. 2021 Multiple sclerosis, for example, has long been associated with infection by the herpesvirus Epstein-Barr. New York Times, 21 Jan. 2021 The second concerned a rise in multiple-sclerosis cases, which some in the population feared was linked to the government’s hepatitis B vaccination program. Yasmeen Serhan, The Atlantic, 18 Mar. 2021 Like many people at the beginning of their ALS journey, Trott’s father was first diagnosed with the less severe primary lateral sclerosis. San Diego Union-Tribune, 16 Mar. 2021 Days later, pathology results determined Isaiah had an extracardiac rhabdomyoma, a rare benign soft-tissue tumor caused by a genetic disease called tuberous sclerosis. Evan Frank, Milwaukee Journal Sentinel, 3 Mar. 2021 The nerves develop scars or sclerotic lesions (sclerosis is Greek for hard) in the aftermath of such attacks. Bret Stetka, Scientific American, 18 June 2015

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'sclerosis.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of sclerosis

1846, in the meaning defined at sense 1

History and Etymology for sclerosis

Middle English sclirosis tumor, from Medieval Latin, from Greek sklērōsis hardening, from sklēroun to harden, from sklēros

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Time Traveler for sclerosis

Time Traveler

The first known use of sclerosis was in 1846

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Statistics for sclerosis

Last Updated

3 Jun 2021

Cite this Entry

“Sclerosis.” Dictionary, Merriam-Webster, Accessed 13 Jun. 2021.

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More Definitions for sclerosis



English Language Learners Definition of sclerosis

medical : a disease in which soft parts inside the body (such as arteries or muscles) become hard


scle·​ro·​sis | \ sklə-ˈrō-səs How to pronounce sclerosis (audio) \
plural scleroses\ -​ˌsēz How to pronounce sclerosis (audio) \

Medical Definition of sclerosis

1 : a pathological condition in which a tissue has become hard and which is produced by overgrowth of fibrous tissue and other changes (as in arteriosclerosis) or by increase in interstitial tissue and other changes (as in multiple sclerosis)

called also hardening

2 : any of various diseases characterized by sclerosis usually used in combination — see arteriosclerosis, multiple sclerosis, myelosclerosis

More from Merriam-Webster on sclerosis

Nglish: Translation of sclerosis for Spanish Speakers

Britannica English: Translation of sclerosis for Arabic Speakers Encyclopedia article about sclerosis


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