scle·​ro·​sis | \ sklə-ˈrō-səs How to pronounce sclerosis (audio) \

Definition of sclerosis

1 : pathological hardening of tissue especially from overgrowth of fibrous tissue or increase in interstitial tissue also : a disease characterized by sclerosis
2 : an inability or reluctance to adapt or compromise political sclerosis

Examples of sclerosis in a Sentence

Recent Examples on the Web Multiple sclerosis is a central nervous system disease that affects the brain and spinal cord. Beth Krietsch, SELF, 22 July 2022 Lawmakers would do well to advance policies that would cure the agency's sclerosis. Sally Pipes, Forbes, 18 July 2022 A year later, scientists reported that pathological TDP-43 was also present in the brains of people with Alzheimer’s disease and hippocampal sclerosis, a disease associated with pathological changes in the hippocampus. Diana Kwon, Scientific American, 13 July 2022 More widely, the failure will speak to the sclerosis of American governance. Robinson Meyer, The Atlantic, 15 June 2022 Multiple sclerosis is a potentially disabling disease of the brain and spinal cord. Ben Thomas |, al, 27 May 2022 Robert Dallek, a historian and biographer of Lyndon B. Johnson, said such sclerosis had ebbed and flowed in the past. New York Times, 30 May 2022 Multiple sclerosis treatments, which cost between $8,000 and $11,000 in the mid-1990s, averaged $60,000 a year by 2015 and reached $80,000 by 2020. Billy Kenber, STAT, 14 May 2022 Biogen’s big-selling multiple-sclerosis franchise, which for years had rung up billions of dollars in sales, is aging and facing fierce competition. Joseph Walker, WSJ, 4 May 2022 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'sclerosis.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of sclerosis

1846, in the meaning defined at sense 1

History and Etymology for sclerosis

Middle English sclirosis tumor, from Medieval Latin, from Greek sklērōsis hardening, from sklēroun to harden, from sklēros

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Time Traveler for sclerosis

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The first known use of sclerosis was in 1846

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Last Updated

2 Aug 2022

Cite this Entry

“Sclerosis.” Dictionary, Merriam-Webster, Accessed 12 Aug. 2022.

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More Definitions for sclerosis


scle·​ro·​sis | \ sklə-ˈrō-səs How to pronounce sclerosis (audio) \
plural scleroses\ -​ˌsēz How to pronounce sclerosis (audio) \

Medical Definition of sclerosis

1 : a pathological condition in which a tissue has become hard and which is produced by overgrowth of fibrous tissue and other changes (as in arteriosclerosis) or by increase in interstitial tissue and other changes (as in multiple sclerosis)

called also hardening

2 : any of various diseases characterized by sclerosis usually used in combination — see arteriosclerosis, multiple sclerosis, myelosclerosis

More from Merriam-Webster on sclerosis

Nglish: Translation of sclerosis for Spanish Speakers

Britannica English: Translation of sclerosis for Arabic Speakers Encyclopedia article about sclerosis


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