reading frame


Definition of reading frame

: a sequence of nucleotide triplets that is potentially translatable into a polypeptide and that is determined by the placement of a codon that initiates translation

Examples of reading frame in a Sentence

Recent Examples on the Web According to a study published in April 2020, mutations identified in the nonstructural protein NSP6 and open reading frame Orf10 likely prevent autophagosomes from delivering material to the lysosome. William A. Haseltine, Forbes, 7 Sep. 2021 It is synthesized as part of two much longer polypeptides, the product of the initial long open reading frame (orf1a), and from the orf1b, the orf1ab polypeptide. William A. Haseltine, Forbes, 4 June 2021 Further mutations to the nucleocapsid protein and open reading frame eight likely increase the virus’s virulence, as similar mutations have been seen in other variants. William A. Haseltine, Forbes, 18 Mar. 2021 For instance, Lanjuan noted a mutation in the open reading frame three at position 251 (G251V). William A. Haseltine, Forbes, 3 Mar. 2021

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'reading frame.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of reading frame

1961, in the meaning defined above

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Time Traveler for reading frame

Time Traveler

The first known use of reading frame was in 1961

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Dictionary Entries Near reading frame

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reading frame

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Statistics for reading frame

Last Updated

7 Jan 2022

Cite this Entry

“Reading frame.” Dictionary, Merriam-Webster, Accessed 27 Jan. 2022.

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More Definitions for reading frame

reading frame

read·​ing frame | \ ˈrēd-iŋ- How to pronounce reading frame (audio) \

Medical Definition of reading frame

: any of the three possible ways of reading a sequence of nucleotides as a series of triplets — see open reading frame


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