as·​par·​tame | \ ˈa-spər-ˌtām How to pronounce aspartame (audio) , ə-ˈspär-ˌtām How to pronounce aspartame (audio) \

Definition of aspartame

: a crystalline compound C14H18N2O5 that is a diamide synthesized from phenylalanine and aspartic acid and that is used as a low-calorie sweetener

Examples of aspartame in a Sentence

Recent Examples on the Web Examples of artificial sweeteners include sucralose and aspartame, while sorbitol and xylitol are some sugar alcohols. Nikhita Mahtani, SELF, 7 June 2022 Three of those approved include aspartame, sucralose, and acesulfame potassium. Joshua Hawkins, BGR, 28 Mar. 2022 High consumers of aspartame registered with a 15 percent greater chance of cancer. Joshua Hawkins, BGR, 28 Mar. 2022 In addition, a study that fed mice sucralose, aspartame, or saccharin for 11 weeks found alterations in the gut microbiome, which caused intolerance to a standardized glucose feeding. Patrick Wilson, Outside Online, 7 Aug. 2020 Chocolate, aged cheeses, salty foods, and food additives like aspartame and MSG are among the ones migraineurs mention most often. Colleen Stinchcombe,, 18 Jan. 2022 Another artificial sweetener, sucralose (aka Splenda®), is even sweeter than saccharin and aspartame, coming in at 600 times the potency of sugar. Patrick Wilson, Outside Online, 7 Aug. 2020 Enough shoppers balked at the new recipe that Pepsi brought the aspartame version back the following year. Danielle Wiener-bronner, CNN, 6 Aug. 2021 The company indicated that the change is more of a tweak than an overhaul, noting that the drink’s ingredient list (including the sweetening blend of aspartame and acesulfame potassium) and nutritional values won’t change., 20 July 2021 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'aspartame.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of aspartame

1972, in the meaning defined above

History and Etymology for aspartame

aspartic acid + phenylalanine + methyl + ester

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Time Traveler for aspartame

Time Traveler

The first known use of aspartame was in 1972

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Dictionary Entries Near aspartame

asparagus stone



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Statistics for aspartame

Last Updated

20 Jun 2022

Cite this Entry

“Aspartame.” Dictionary, Merriam-Webster, Accessed 26 Jun. 2022.

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More Definitions for aspartame


as·​par·​tame | \ ˈas-pər-ˌtām How to pronounce aspartame (audio) , ə-ˈspär- How to pronounce aspartame (audio) \

Medical Definition of aspartame

: a crystalline dipeptide ester C14H18N2O5 that is synthesized from the amino acids phenylalanine and aspartic acid and is used as a low-calorie sweetener — see nutrasweet

More from Merriam-Webster on aspartame Encyclopedia article about aspartame


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