off-label

adjective

off-la·​bel ˈȯf-ˌlā-bəl How to pronounce off-label (audio)
: of, relating to, or being a drug used to treat a condition for which it has not been officially approved

Examples of off-label in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Once used primarily for managing blood sugar, they are now being prescribed off-label for weight loss, catalyzing a seismic shift in how society views health, weight and medical intervention. Stephen Sokoler, Forbes.com, 26 June 2025 The actor had been using the drug through his regular doctor in a legal but off-label treatment for depression that has become increasingly common. Perry, 54, began seeking more ketamine than his doctor would give him. Andrew Dalton, Chicago Tribune, 16 June 2025 SSRIs are approved by the FDA to treat a range of conditions such as anxiety, depression, bulimia nervosa, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD), and are used off-label to treat several others. Adrianna Rodriguez, USA Today, 22 May 2025 The drug is often prescribed for off-label use to treat a range of pain conditions, studies show. Melissa Rudy, FOXNews.com, 21 May 2025 See All Example Sentences for off-label

Word History

First Known Use

1987, in the meaning defined above

Time Traveler
The first known use of off-label was in 1987

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Cite this Entry

“Off-label.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/off-label. Accessed 3 Jul. 2025.

Medical Definition

off-label

adjective
off-la·​bel ˌȯf-ˌlā-bəl How to pronounce off-label (audio)
: of, relating to, or being an approved drug legally prescribed or a medical device legally used by a physician for a purpose (as the treatment of children or of a certain disease or condition) for which it has not been specifically approved (as by the United States Food and Drug Administration)
the off-label use of oral contraceptives to treat dysmenorrhea
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