nucleophilic

adjective

nu·​cle·​o·​phil·​ic ˌnü-klē-ə-ˈfi-lik How to pronounce nucleophilic (audio)
ˌnyü-
1
of an atom, ion, or molecule : having an affinity for atomic nuclei : being an electron donor
2
: involving a nucleophilic species
a nucleophilic reaction
compare electrophilic

Examples of nucleophilic in a Sentence

Recent Examples on the Web
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It can be synthesized in a number of ways—Liu’s team has experimented with making it from various nucleophilic agents, solvents, and mechanical supports—but the key starting ingredients always include lithium sulfide (Li2S) and phosphorus sulfide (P2S5). — IEEE Spectrum, 3 Feb. 2020

Word History

First Known Use

1933, in the meaning defined at sense 1

Time Traveler
The first known use of nucleophilic was in 1933

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Cite this Entry

“Nucleophilic.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/nucleophilic. Accessed 26 Sep. 2026.

Medical Definition

nucleophilic

adjective
1
of an atom, ion, or molecule : having an affinity for atomic nuclei : being an electron donor
2
: involving a nucleophilic species
a nucleophilic reaction
nucleophilicity noun
plural nucleophilicities
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