macrophage

noun

mac·​ro·​phage ˈma-krə-ˌfāj How to pronounce macrophage (audio)
: a phagocytic tissue cell of the immune system that may be fixed or freely motile, is derived from a monocyte, functions in the destruction of foreign antigens (such as bacteria and viruses), and serves as an antigen-presenting cell compare histiocyte
macrophagic adjective

Examples of macrophage in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Their beta-glucans have been shown to activate key immune cells like macrophages and natural killer cells, supporting the body’s frontline defenses. Alessandra Signorelli, Vogue, 13 Feb. 2026 Because the brain has ordered the macrophages to create an immunosuppressive shield, the T cells lose their energy, stop multiplying and fail to recognize the cancer as a threat. Jacek Krywko, Scientific American, 4 Feb. 2026 Primer extension experiments using mouse macrophage RNA indicated a single transcriptional initiation site. Kirstin R.w. Matthews, STAT, 3 Feb. 2026 Symptom Relief Zinc can also boost the immune system by increasing the number of T cells and macrophages that fight infection. Ayesha Gulzar, Verywell Health, 13 Jan. 2026 See All Example Sentences for macrophage

Word History

Etymology

borrowed from German Makrophagen (plural), from makro- macro- + -phagen, plural of -phage -phage

Note: Introduced, along with Mikrophagen "microphages," by Élie metchnikoff in "Ueber den Kampf der Zellen gegen Erysipelkokken," Archiv für pathologische Anatomie und Physiologie, Band 107 (1887), p. 222.

First Known Use

1887, in the meaning defined above

Time Traveler
The first known use of macrophage was in 1887

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Cite this Entry

“Macrophage.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/macrophage. Accessed 26 Feb. 2026.

Kids Definition

macrophage

noun
mac·​ro·​phage ˈmak-rə-ˌfāj How to pronounce macrophage (audio)
: a large phagocyte of the immune system

Medical Definition

macrophage

noun
mac·​ro·​phage ˈmak-rə-ˌfāj How to pronounce macrophage (audio) -ˌfäzh How to pronounce macrophage (audio)
: a phagocytic tissue cell of the immune system that may be fixed or freely motile, is derived from a monocyte, functions in the destruction of foreign antigens (as bacteria and viruses), and serves as an antigen-presenting cell see histiocyte, mononuclear phagocyte system
macrophagic adjective

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