ki·​nase | \ ˈkī-ˌnās How to pronounce kinase (audio) , -ˌnāz \

Definition of kinase

: any of various enzymes that catalyze the transfer of phosphate groups from a high-energy phosphate-containing molecule (such as ATP) to a substrate — compare protein kinase

Examples of kinase in a Sentence

Recent Examples on the Web Tanzi and his colleagues blocked a variety of different enzymes called kinases to try to stop the process. Karen Weintraub, Scientific American, "Possible Missing Link in Alzheimer’s Pathology Identified," 16 Jan. 2020 ArQule, based in Woburn, Mass., is focused on kinase inhibitor discovery. Washington Post, "GM to lend $40 million to start-up for Lordstown," 9 Dec. 2019 Dumbfounded but also aware that my own primary care doctor is vigilant about my A1c level (a measure of diabetes) and an enzyme calledcreatine kinase (a sign of heart disease) but never asks about my mental health. Steven Petrow,, "Six questions that may help stop a suicide," 23 Sep. 2019 The drug belongs to a large class of cancer drugs called tyrosine kinase inhibitors, the fruits of research by Tony Hunter at the Salk Institute four decades ago. San Diego Union-Tribune, "Turning Point Therapeutics raises $202 million for cancer therapy," 17 Sep. 2019 For his part, Hunter performed research that led to an entirely new category of cancer drugs called tyrosine kinase inhibitors. San Diego Union-Tribune, "Once shelved as too risky, blood cancer drug discovered in San Diego gets FDA approval," 19 Aug. 2019 Most recently, autoimmune drugs known as Janus kinase inhibitors -- JAK inhibitors -- have been found to produce a full head of hair in patients with moderate to severe alopecia areata, a type of baldness that affects both men and women. Susan Scutti, CNN, "Side effects include ... a potential treatment for baldness," 9 May 2018 In February, for example, Hyman and co-authors reported in The New England Journal of Medicine that a drug aimed at genes known as tropomyosin receptor kinase (TRK) fusions works for many tumor types. Jocelyn Kaiser, Science | AAAS, "A cancer drug tailored to your tumor? Experts trade barbs over ‘precision oncology’," 24 Apr. 2018 Hunter made his reputation with the 1979 discovery of how enzymes called tyrosine kinases can cause cancer. Bradley J. Fikes,, "Superstar cancer researcher Tony Hunter of Salk Institute wins award, makes new finding," 4 Apr. 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'kinase.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of kinase

1947, in the meaning defined above

History and Etymology for kinase

International Scientific Vocabulary, from kinetic

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Time Traveler for kinase

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The first known use of kinase was in 1947

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Last Updated

23 Feb 2020

Cite this Entry

“Kinase.” Dictionary, Merriam-Webster, Accessed 27 Feb. 2020.

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More Definitions for kinase


ki·​nase | \ ˈkī-ˌnās, -ˌnāz How to pronounce kinase (audio) \

Medical Definition of kinase

: any of various enzymes that catalyze the transfer of phosphate groups from a high-energy phosphate-containing molecule (as ATP or ADP) to a substrate

called also phosphokinase

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More from Merriam-Webster on kinase

Rhyming Dictionary: Words that rhyme with kinase

Nglish: Translation of kinase for Spanish Speakers Encyclopedia article about kinase

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