kinase
noun
-ˌnāz\
Definition of kinase
: any of various enzymes that catalyze the transfer of phosphate groups from a high-energy phosphate-containing molecule (such as ATP) to a substrate — compare protein kinase
Examples of kinase in a Sentence
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Choanoflagellates have genes for tyrosine kinases, enzymes that, in complex animals, help control the functions of specialized cells, such as insulin secretion in the pancreas. — Elizabeth Pennisi, Science | AAAS, "The momentous transition to multicellular life may not have been so hard after all," 28 June 2018 Both monoclonal antibodies and tyrosine kinases now provide the basis for many new medicines coming to market. — Fred D. Ledley, STAT, "30 years is too long to wait for new medicines. There are ways to speed up drug development," 6 June 2018 Hunter made his reputation with the 1979 discovery of how enzymes called tyrosine kinases can cause cancer. — Bradley J. Fikes, sandiegouniontribune.com, "Superstar cancer researcher Tony Hunter of Salk Institute wins award, makes new finding," 4 Apr. 2018 Most recently, autoimmune drugs known as Janus kinase inhibitors -- JAK inhibitors -- have been found to produce a full head of hair in patients with moderate to severe alopecia areata, a type of baldness that affects both men and women. — Susan Scutti, CNN, "Side effects include ... a potential treatment for baldness," 9 May 2018 In February, for example, Hyman and co-authors reported in The New England Journal of Medicine that a drug aimed at genes known as tropomyosin receptor kinase (TRK) fusions works for many tumor types. — Jocelyn Kaiser, Science | AAAS, "A cancer drug tailored to your tumor? Experts trade barbs over ‘precision oncology’," 24 Apr. 2018 Spectrum of discovery The Nature study can be viewed as an extension of Hunter’s groundbreaking work in tyrosine kinases. — Bradley J. Fikes, sandiegouniontribune.com, "Superstar cancer researcher Tony Hunter of Salk Institute wins award, makes new finding," 4 Apr. 2018 The class of cancer drugs that block phosphorylation activity are called tyrosine kinase inhibitors. — Bradley J. Fikes, sandiegouniontribune.com, "Superstar cancer researcher Tony Hunter of Salk Institute wins award, makes new finding," 4 Apr. 2018 The team at Stamford has previously determined the role of homeodomain-interacting protein kinase 4 (HIPK4) in the later stages of spermatogenesis, and it is thought that a drug targeting this kinase could be used as a contraceptive. — Hannah Flynn, Ars Technica, "More than half a century later, where’s the male pill?," 28 Feb. 2018These example sentences are selected automatically from various online news sources to reflect current usage of the word 'kinase.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.
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More Definitions for kinase
kinase
noun
\
Medical Definition of kinase
: any of various enzymes that catalyze the transfer of phosphate groups from a high-energy phosphate-containing molecule (as ATP or ADP) to a substrate
— called also
phosphokinase
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