protein kinase


: any of a class of enzymes that catalyze the transfer of a phosphate group from ATP to one or more amino acids in the side chain of a protein resulting in a conformational change affecting protein function

Examples of protein kinase in a Sentence

Recent Examples on the Web Examples include monoclonal antibodies, angiogenesis inhibitors, and protein kinase inhibitors. Taylyn Washington-Harmon, Health, 16 Dec. 2023 The disorder, an abbreviation for calcium/calmodulin dependent protein kinase 2, impacts mobility and brain function. Brenton Blanchet, Peoplemag, 26 June 2023 The team at Stamford has previously determined the role of homeodomain-interacting protein kinase 4 (HIPK4) in the later stages of spermatogenesis, and it is thought that a drug targeting this kinase could be used as a contraceptive. Hannah Flynn, Ars Technica, 28 Feb. 2018 Hall was honored for his work in discovering how a large family of nutrient-dependent protein kinases, called the TOR proteins, play a central role in controlling the cell growth. Beth Mole, Ars Technica, 6 Sep. 2017

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'protein kinase.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1962, in the meaning defined above

Time Traveler
The first known use of protein kinase was in 1962

Dictionary Entries Near protein kinase

Cite this Entry

“Protein kinase.” Dictionary, Merriam-Webster, Accessed 19 Jun. 2024.

Medical Definition

protein kinase

: any of a class of allosteric enzymes that possess a catalytic subunit which transfers a phosphate from ATP to one or more amino acid residues (as serine, threonine, or tyrosine) in a protein's side chain resulting in a conformational change affecting protein function, that play a role in regulating intracellular processes, and that include many which are activated by the binding of a second messenger (as cyclic AMP)
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