protein kinase

noun

: any of a class of enzymes that catalyze the transfer of a phosphate group from ATP to one or more amino acids in the side chain of a protein resulting in a conformational change affecting protein function

Example Sentences

Recent Examples on the Web The team at Stamford has previously determined the role of homeodomain-interacting protein kinase 4 (HIPK4) in the later stages of spermatogenesis, and it is thought that a drug targeting this kinase could be used as a contraceptive. Hannah Flynn, Ars Technica, 28 Feb. 2018 Hall was honored for his work in discovering how a large family of nutrient-dependent protein kinases, called the TOR proteins, play a central role in controlling the cell growth. Beth Mole, Ars Technica, 6 Sep. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'protein kinase.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

Word History

First Known Use

1962, in the meaning defined above

Time Traveler
The first known use of protein kinase was in 1962

Dictionary Entries Near protein kinase

Cite this Entry

“Protein kinase.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/protein%20kinase. Accessed 30 Nov. 2022.

Medical Definition

protein kinase

noun

: any of a class of allosteric enzymes that possess a catalytic subunit which transfers a phosphate from ATP to one or more amino acid residues (as serine, threonine, or tyrosine) in a protein's side chain resulting in a conformational change affecting protein function, that play a role in regulating intracellular processes, and that include many which are activated by the binding of a second messenger (as cyclic AMP)
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