familial hypercholesterolemia
noun
: an inherited metabolic disorder marked by excess accumulation of LDL cholesterol in the blood resulting especially in atherosclerosis and irregular yellow skin lesions
Examples of familial hypercholesterolemia in a Sentence
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For example, people with familial hypercholesterolemia, a genetic condition that causes high LDL cholesterol levels, are more sensitive to dietary fats.
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Jillian Kubala, Health, 15 Jan. 2025
Though your body needs fat to function and fat isn't inherently bad for your health, some people, such as those with familial hypercholesterolemia, are more sensitive to high-fat, high-cholesterol foods like cheese.
—Jillian Kubala, Health, 1 July 2024
Other heart conditions, like familial hypercholesterolemia (high cholesterol) and high lipoprotein (a) (proteins and fats that carry cholesterol), can be inherited, and a family history of heart disease that isn’t genetic puts you at higher risk, too.
—Sarah Klein, TIME, 11 Apr. 2024
The 10 patients in this Phase 1 trial had heterozygous familial hypercholesterolemia, a genetic disease that causes high levels of bad cholesterol and advanced heart disease.
—Meghana Keshavan, STAT, 13 Nov. 2023
Verve's research was limited to people with a genetic condition called heterozygous familial hypercholesterolemia, in which cholesterol levels are sky-high from birth.
—Erika Edwards, NBC News, 12 Nov. 2023
Each had a genetic abnormality, familial hypercholesterolemia, that affects around one million people in the United States.
—Gina Kolata, New York Times, 12 Nov. 2023
Although the trial is focused on people with the genetic condition familial hypercholesterolemia, Kathiresan hopes the one-and-done therapy may one day be used more broadly, to permanently reduce the risk of heart disease in millions of people with high cholesterol.
—Ryan Cross, BostonGlobe.com, 12 July 2022
Current drugs available for familial hypercholesterolemia lower LDL cholesterol by as much as 50 to 60 percent, but they must be injected once or twice a month, a schedule many patients have a hard time sticking to, said Dr. Gary Balady, director of preventative cardiology at Boston Medical Center.
—Ryan Cross, BostonGlobe.com, 12 July 2022
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Jillian Kubala, Health, 15 Jan. 2025
Though your body needs fat to function and fat isn't inherently bad for your health, some people, such as those with familial hypercholesterolemia, are more sensitive to high-fat, high-cholesterol foods like cheese.
—Jillian Kubala, Health, 1 July 2024
Other heart conditions, like familial hypercholesterolemia (high cholesterol) and high lipoprotein (a) (proteins and fats that carry cholesterol), can be inherited, and a family history of heart disease that isn’t genetic puts you at higher risk, too.
—Sarah Klein, TIME, 11 Apr. 2024
The 10 patients in this Phase 1 trial had heterozygous familial hypercholesterolemia, a genetic disease that causes high levels of bad cholesterol and advanced heart disease.
—Meghana Keshavan, STAT, 13 Nov. 2023
Verve's research was limited to people with a genetic condition called heterozygous familial hypercholesterolemia, in which cholesterol levels are sky-high from birth.
—Erika Edwards, NBC News, 12 Nov. 2023
Each had a genetic abnormality, familial hypercholesterolemia, that affects around one million people in the United States.
—Gina Kolata, New York Times, 12 Nov. 2023
Although the trial is focused on people with the genetic condition familial hypercholesterolemia, Kathiresan hopes the one-and-done therapy may one day be used more broadly, to permanently reduce the risk of heart disease in millions of people with high cholesterol.
—Ryan Cross, BostonGlobe.com, 12 July 2022
Current drugs available for familial hypercholesterolemia lower LDL cholesterol by as much as 50 to 60 percent, but they must be injected once or twice a month, a schedule many patients have a hard time sticking to, said Dr. Gary Balady, director of preventative cardiology at Boston Medical Center.
—Ryan Cross, BostonGlobe.com, 12 July 2022
Cite this Entry
“Familial hypercholesterolemia.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/familial%20hypercholesterolemia. Accessed 26 Jul. 2025.
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