downstream

adverb or adjective

down·​stream ˈdau̇n-ˈstrēm 

1

: in the direction of or nearer to the mouth of a stream

floating downstream

located two miles downstream

2

: in or toward the latter stages of a usually industrial process or the stages (such as marketing) after manufacture

improving profits downstream

downstream products

3

biochemistry : toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence

But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.

—Marcia Barinaga

Examples of downstream in a Sentence

Recent Examples on the Web

While those other factors are important, every process in the body exists downstream of energy flow, Picard says — for cortisol to rise, for neurons to fire, for the microbiome to function, energy has to move through the system. —Jasna Hodžić, Big Think, 22 Apr. 2026

The water in Antero Reservoir will be moved downstream to Cheesman Reservoir, southwest of Deckers. —Elise Schmelzer, Denver Post, 20 Apr. 2026

Chongming Island is the third-largest island in China and the largest alluvial island on Earth, built over centuries from sediment carried downstream by the Yangtze River. —Hanna Wickes, Kansas City Star, 20 Apr. 2026

The study got its start when co-author Brian Gootee, a geologist with the Arizona Geological Survey, noticed a resemblance between sand deposits downstream of the Grand Canyon and in the Bidahochi—both contained pink, rounded grains that seemed to have been transported by the same river. —Cody Cottier, Scientific American, 16 Apr. 2026

Word History

First Known Use

1591, in the meaning defined at sense 1

Rhymes for downstream

• abeam
• airstream
• bloodstream
• daydream
• esteem
• extreme
• grapheme
• hakim
• hornbeam
• lexeme
• mainstream
• midstream

Kids Definition

downstream

adverb or adjective

down·​stream ˈdau̇n-ˈstrēm 

: in the direction a stream is flowing

Medical Definition

downstream

adverb or adjective

down·​stream ˌdau̇n-ˈstrēm 

1

: in the same direction along a molecule of DNA or RNA as that in which transcription and translation take place and toward the end having a hydroxyl group attached to the position labeled 3′ in the terminal nucleotide

a nucleotide sequence located downstream from the regulatory gene

effects on the expression of downstream genes

compare upstream sense 1

2

: toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence

But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.

—Marcia Barinaga, Science

The tyrosine kinase activity of phosphorylated EGFR [epidermal growth factor receptor] in cancer cells results in the phosphorylation of downstream proteins that incite cell proliferation, invasion, metastasis, and inhibition of apoptosis.

—Jonathan E. Dowell and John D. Minna, The New England Journal of Medicine