cortisol

noun

cor·​ti·​sol ˈkȯr-tə-ˌsȯl 

-ˌzȯl,

-ˌsōl,

-ˌzōl

: a glucocorticoid C₂₁H₃₀O₅ produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

Examples of cortisol in a Sentence

Recent Examples on the Web

Have unbalanced and excessive cortisol? —Margaux Anbouba, Vogue, 11 Sep. 2025

Although reducing your underlying stress is the best way to balance your cortisol, some supplements can also help balance your cortisol levels. —Heidi Cope, Health, 8 Sep. 2025

In fact, research suggests massage can significantly lower levels of cortisol, which is a stress hormone that your body makes. —Julie Marks, Verywell Health, 4 Sep. 2025

The supplement also contains a blend of plant extracts shown to support digestion, cortisol, progesterone and estrogen levels to assist in weight management, reduce flatulence, decrease occasional heart burn, relieve mild gastrointestinal tract discomfort, and curb carb cravings. —Chloe Castleberry, Flow Space, 3 Sep. 2025

Word History

Etymology

cortisone + -ol entry 1

First Known Use

1951, in the meaning defined above

Rhymes for cortisol

• aerosol
• alcohol
• arbitral
• basketball
• butanol
• cannonball
• carbinol
• catarrhal
• ethanol
• fireball
• gasohol
• guaiacol

Medical Definition

cortisol

noun

cor·​ti·​sol ˈkȯrt-ə-ˌsȯl, -ˌzȯl, -ˌsōl, -ˌzōl 

: a glucocorticoid C₂₁H₃₀O₅ produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone