Definition of antisense
: having a sequence complementary to a segment of genetic material
specifically
: of, being, relating to, or possessing a sequence of DNA or RNA that is complementary to and pairs with a specific messenger RNA blocking it from being translated into protein and serving to inhibit gene function
antisense drug therapy antisense RNA
— compare missense, nonsense
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Merriam-Webster unabridged
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Time Traveler for antisense
The first known use of antisense was in 1977
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