Cooley's anemia

noun
Coo·​ley's anemia | \ˈkü-lēz- \

Definition of Cooley's anemia 

: an inherited disorder of hemoglobin synthesis that is the most severe form of beta-thalassemia, is marked by severe anemia associated with deficient hemoglobin, the presence of microcytes, and accelerated red cell destruction, and is associated with enlargement of the liver and spleen, an increase in erythroid bone marrow, bone deformities, and poor growth rate

Note: Cooley's anemia is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene located on the chromosome numbered 11. Cooley's anemia occurs especially in individuals of Mediterranean ancestry and necessitates regular blood transfusions throughout life.

First Known Use of Cooley's anemia

1934, in the meaning defined above

History and Etymology for Cooley's anemia

Thomas B. Cooley †1945 American pediatrician

Keep scrolling for more

Learn More about Cooley's anemia

Share Cooley's anemia

Dictionary Entries near Cooley's anemia

coolerman

cooler nail

cooley

Cooley's anemia

coolheaded

coolhouse

Coolidge

Statistics for Cooley's anemia

Look-up Popularity

Time Traveler for Cooley's anemia

The first known use of Cooley's anemia was in 1934

See more words from the same year

Keep scrolling for more

More Definitions for Cooley's anemia

Cooley's anemia

noun
Coo·​ley's anemia | \ˌkü-lēz- \
variants: also Cooley's disease

Medical Definition of Cooley's anemia 

: an inherited disorder of hemoglobin synthesis that is the most severe form of beta-thalassemia, is marked by severe anemia associated with deficient hemoglobin, the presence of microcytes, and accelerated red cell destruction, and is associated with enlargement of the liver and spleen, an increase in the erythroid bone marrow, bone deformities, and poor growth rate

called also beta-thalassemia major, thalassemia major

Note: Cooley's anemia is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene located on the chromosome numbered 11. Cooley's anemia occurs especially in individuals of Mediterranean ancestry and necessitates regular blood transfusions throughout life.

Comments on Cooley's anemia

What made you want to look up Cooley's anemia? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

a private place of worship

Get Word of the Day daily email!

Test Your Vocabulary

Difficult Vocab Quiz

  • the-education-of-achilles-eugne-delacroix
  • Which is a synonym of discomfit?
Name That Thing

Test your visual vocabulary with our 10-question challenge!

TAKE THE QUIZ
Syn City

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!