Anagrams require a particular kind of skill, and they have for a long time. That is, anagrams are difficult and ancient. Or, to put it into an anagram, trim an id uncle after fan smartens cad again. The best anagrams make sense in both of their forms, though, so, ahem, we'll emphasize the "difficult" here.
The ancient Greeks and Romans made anagrams, and anagrams were popular throughout Medieval Europe. In the 16th and 17th centuries religious orders made anagrams as a kind of exercise, taking, for example, the angelical salutation "Ave Maria, gratia plena, Dominus tecum” (“Hail Mary, full of grace, the Lord is with thee”) and creating hundreds of variations, among them “Virgo serena, pia, munda et immaculata” (“Virgin serene, holy, pure, and immaculate”). Computers simplify the process immeasurably, which means we are, in fact, in a new golden age of anagrams.