as in downfall
something that is the cause of one's ultimate failure or loss of life Bringing the work files proved to be the kiss of death for what may have been a relaxing vacation.

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“Kiss of death.” Merriam-Webster.com Thesaurus, Merriam-Webster, https://www.merriam-webster.com/thesaurus/kiss%20of%20death. Accessed 2 Dec. 2022.

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