tissue

noun

tis·​sue ˈti-(ˌ)shü 

chiefly British ˈtis-(ˌ)yü

1

: a piece of soft absorbent tissue paper used especially as a handkerchief or for removing cosmetics

2

: an aggregate of cells usually of a particular kind together with their intercellular substance that form one of the structural materials of a plant or an animal

3

a

: a fine lightweight often sheer fabric

b

: mesh, network, web

a tissue of lies

tissuey

ˈti-shə-wē 

adjective

Examples of tissue in a Sentence

She wiped her nose with a tissue.

a sample of brain tissue

The drug can damage the body's tissues.

a box wrapped in tissue

Recent Examples on the Web

Rachel Perry, PhD, has spent most of her scientific life thinking about how the body moves energy around—how glucose rises and falls, how tissues compete for fuel, and how metabolism shifts during illness. —Avi Patel, Hartford Courant, 30 Jan. 2026

The goal of a morning routine is to allow joints and tissues to regain safe, functional motion before being asked to stabilize or bear load. —Dana Santas, CNN Money, 30 Jan. 2026

So, grab the tissues and pour yourself a glass of wine because these movies are an emotional rollercoaster. —Ryan Brennan, Miami Herald, 30 Jan. 2026

Human fetal tissue research has helped in the development of some vaccines. —Mary Kekatos, ABC News, 29 Jan. 2026

Word History

Etymology

Middle English tysshewe, tyssew, a rich fabric, from Anglo-French tissue, from past participle of tistre to weave, from Latin texere — more at technical

First Known Use

1563, in the meaning defined at sense 3a

Phrases Containing tissue

• adipose tissue
• bathroom tissue
• connective tissue
• granulation tissue
• permanent tissue
• scar tissue
• tissue culture
• tissue fluid
• tissue of lies
• tissue paper
• tissue plasminogen activator
• vascular tissue
• woven a tissue of lies

Rhymes for tissue

• blew
• blue
• boo
• brew
• chew
• chou
• clue
• coo
• coup
• crew
• cue
• dew

Kids Definition

tissue

noun

tis·​sue ˈtish-ü 

1

: a fine lightweight fabric

2

: a piece of soft absorbent paper

3

: a mass or layer of cells usually of one kind together with the uniting or enclosing substance around and between them that form the basic structural materials of a plant or an animal compare connective tissue

Medical Definition

tissue

noun

tis·​sue

ˈtish-(ˌ)ü, ˈtish-ə(-w), chiefly British ˈtis-(ˌ)yü

: an aggregate of cells usually of a particular kind together with their intercellular substance that form one of the structural materials of a plant or an animal and that in animals include connective tissue, epithelium, muscle tissue, and nerve tissue