interstitial
adjective
in·ter·sti·tial
ˌin-tər-ˈsti-shəl 
1
: occurring in or being an interval or intervening space or segment : of, relating to, or forming an interstice
an interstitial space
… the site has been running interstitial ads, which consist of a full page of advertising between editorial pages, for a little more than a year.—
Carl Sullivan
Carl Sullivan2
a
: situated within but not restricted to or characteristic of a particular organ or tissue
—used especially of fibrous tissue
b
: affecting the interstitial tissues of an organ or part
interstitial cystitis
3
: being or relating to a crystalline compound in which usually small atoms or ions of a nonmetal occupy holes between the larger metal atoms or ions in the crystal lattice
Examples of interstitial in a Sentence
Recent Examples on the Web
These types of wearables provide constant analysis via interstitial fluid, but only after inserting a sensor wire under the skin.
—Andrew Paul, Popular Science, 3 Dec. 2025
In his growing spate of work in Safdie films and Weeknd albums, producer Daniel Lopatin has developed an aptitude for all sorts of heady interstitial and incidental music.
—Craig Jenkins, Vulture, 2 Dec. 2025
Researchers observed healthy cats and those with feline interstitial cystitis—a chronic illness characterized by recurring discomfort or pain in the bladder with an urgent need to urinate.
—Liz O'Connell, MSNBC Newsweek, 25 Nov. 2025
The conditions leading to the actress’s death included an interstitial lung disease that had been progressing for years, with esophageal dysmotility listed as another significant contributing factor.
—Ashley Hume, FOXNews.com, 18 Nov. 2025
See All Example Sentences for interstitial
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Andrew Paul, Popular Science, 3 Dec. 2025
In his growing spate of work in Safdie films and Weeknd albums, producer Daniel Lopatin has developed an aptitude for all sorts of heady interstitial and incidental music.
—Craig Jenkins, Vulture, 2 Dec. 2025
Researchers observed healthy cats and those with feline interstitial cystitis—a chronic illness characterized by recurring discomfort or pain in the bladder with an urgent need to urinate.
—Liz O'Connell, MSNBC Newsweek, 25 Nov. 2025
The conditions leading to the actress’s death included an interstitial lung disease that had been progressing for years, with esophageal dysmotility listed as another significant contributing factor.
—Ashley Hume, FOXNews.com, 18 Nov. 2025
See All Example Sentences for interstitial
Cite this Entry
“Interstitial.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/interstitial. Accessed 11 Dec. 2025.
Copy CitationKids Definition
interstitial
adjective
in·ter·sti·tial
ˌint-ər-ˈstish-əl
: relating to or located in the interstices
Medical Definition
interstitial
adjective
in·ter·sti·tial
ˌint-ər-ˈstish-əl
1
: situated within but not restricted to or characteristic of a particular organ or tissue
—used especially of fibrous tissue
2
: affecting the interstitial tissues of an organ or part
interstitial hepatitis
3
: occurring in the part of a fallopian tube in the wall of the uterus
interstitial pregnancy
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