: a habit-forming compound that is derived from codeine and is administered in the form of its bitartrate C18H21NO3·C4H6O6 usually in combination with other drugs (as acetaminophen) as an analgesic or cough suppressant

Examples of hydrocodone in a Sentence

Recent Examples on the Web
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Two hydrocodone pills were later found in Woods’ pocket, according to an arrest affidavit released by the Martin County Sheriff’s Office and reviewed by The Athletic. Bob Harkins, New York Times, 2 Sep. 2026 An arrest affidavit revealed that deputies who searched Woods at the scene discovered two white pills in his pants pocket that were determined to be the opioid hydrocodone. Kathleen Perricone, Entertainment Weekly, 2 Sep. 2026 At the time of his arrest, Martin County Sheriff’s Office deputies allegedly found Woods carrying hydrocodone pills in his pocket, according to a probable cause affidavit obtained by PEOPLE. Charna Flam, PEOPLE, 2 Sep. 2026 The startup’s Phase 2 trial enrolled 343 patients who’d gotten tummy tuck surgery; they were randomized to receive a high or low dose of Latigo’s experimental pill, a placebo, or a combination of acetaminophen and the opioid hydrocodone. Jonathan Wosen, STAT, 29 July 2026 See All Example Sentences for hydrocodone

Word History

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of hydrocodone was in 1964

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Cite this Entry

“Hydrocodone.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/hydrocodone. Accessed 14 Sep. 2026.

Medical Definition

hydrocodone

noun
: a habit-forming compound derived from codeine and administered in the form of its bitartrate C18H21NO3·C4H6O6 usually in combination with other drugs (as acetaminophen) as an analgesic or cough sedative

called also dihydrocodeinone

see hycodan, vicodin
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