genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

The team estimated the bedbugs’ numbers over time by examining genetic mutations and modeling how large a population would have to be to create them, reports Science’s Rodrigo Pérez Ortega. —Sara Hashemi, Smithsonian Magazine, 28 May 2025

Genetic glitch behind orange cats Step one was to identify genetic mutations that are unique to orange cats and might give rise to their color. —Amanda Schupak, CNN Money, 23 May 2025

Yet, the disease’s complexity, encompassing hundreds of types, each with unique genetic mutations that rapidly mature, migrate and evolve, has slowed progress. —Max Votek, Forbes.com, 22 May 2025

The doctors had started collaborating in 2023, working on ways to correct genetic mutations in young children with ultra-rare diseases. —Vanessa Etienne, People.com, 17 May 2025

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper