Medical Dictionary


noun co·ag·u·la·tion \kō-ˌag-yə-ˈlā-shən\

Medical Definition of coagulation

  1. 1a:  a change to a viscous, jellylike, or solid state; especially :  a change from a liquid to a thickened curdlike state not by evaporation but by chemical reaction <the spontaneous coagulation of freshly drawn blood> <the coagulation of milk by rennin>b:  the process by which such change of state takes place consisting of the alteration of a soluble substance (as a protein) into an insoluble form or of the flocculation or separation of colloidal or suspended matter

  2. 2:  a substance or body formed by coagulation :  coagulum

  3. 3:  disruption of tissue by physical means (as by application of an electric current) so that denaturation and clumping of protein occur <diathermic coagulation of tissues during surgery to seal bleeding blood vessels>—see electrocoagulation, photocoagulation

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