Medical Dictionary

autophagosome

noun au·to·phago·some \ ˌȯ-tō-ˈfag-ə-ˌsōm \

medical Definition of autophagosome

: a double membrane-bound vesicle that encloses cellular constituents and fuses with lysosomes which digest these cellular constituents during autophagy
  • The autophagosome does not bud off from preexisting organelles but, rather, is formed by a dynamic process of membrane expansion.
  • —Daniel J. KlionskyThe New England Journal of Medicine23 Apr. 2009
  • During autophagy, a portion of cytoplasm is sequestered into an autophagosome: this then fuses with the lysosome, and the cytoplasm-derived materials are degraded.
  • —Satoshi Tsukamoto et al.Science4 July 2008

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