autophagy
noun
au·toph·a·gy
ȯ-ˈtä-fə-jē 
: the biological process that involves the enzymatic breakdown of a cell's cytoplasm or cytoplasmic components (such as damaged or unneeded organelles or proteins) within the lysosomes of the same cell
Most of the time, cells sweep away this debris. They even recycle it for fuel. Through the process of autophagy, or "self-eating," cells create specialized membranes that engulf junk in the cytoplasm and carry it to a region of the cell called the lysosome, where the waste is broken down and burned for energy.—
Gretchen Reynolds
Gretchen ReynoldsCertain environmental cues (such as starvation, high temperature, low oxygen, hormonal stimulation) or intracellular stress (damaged organelles, accumulation of mutant proteins, microbial invasion) activate signalling pathways that increase autophagy.—Beth Levine
Beth Levine… proliferating [cancer] cells maintain a nutrient supply by hijacking a natural cell-housekeeping process called autophagy, in which cells chop up and dispose of damaged or obsolete cell components such as proteins.—Nathan Seppa
Nathan SeppaExamples of autophagy in a Sentence
Recent Examples on the Web
This high-energy molecule drives key cellular processes such as endocytosis (bringing substances into cells) and autophagy (clearing cellular waste).
—New Atlas, 6 Aug. 2025
However, research also suggests that at 18 hours other benefits occur (including positive effects on human growth hormone production, the immune system, and autophagy, which replaces older and less functional body cells).
—Bryant Stamford, The Courier-Journal, 8 Aug. 2024
Two modules were especially likely to be disrupted in patients with Alzheimer’s: One included proteins involved in degrading and reprocessing proteins and organelles through processes like autophagy and ubiquitination, while the other was involved in glycolysis, the processing of sugars.
—Rohan Rajeev, STAT, 28 June 2024
The proteins encoded bring together three important functions of the cell: autophagy, immunity and mitochondrial function.
—Matthew Farrer, Discover Magazine, 13 Apr. 2024
All of this is done to have her body in a state of autophagy, which is the way our body moves out unnecessary and dysfunctional cellular components.
—Victoria Uwumarogie, Essence, 3 Oct. 2023
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New Atlas, 6 Aug. 2025
However, research also suggests that at 18 hours other benefits occur (including positive effects on human growth hormone production, the immune system, and autophagy, which replaces older and less functional body cells).
—Bryant Stamford, The Courier-Journal, 8 Aug. 2024
Two modules were especially likely to be disrupted in patients with Alzheimer’s: One included proteins involved in degrading and reprocessing proteins and organelles through processes like autophagy and ubiquitination, while the other was involved in glycolysis, the processing of sugars.
—Rohan Rajeev, STAT, 28 June 2024
The proteins encoded bring together three important functions of the cell: autophagy, immunity and mitochondrial function.
—Matthew Farrer, Discover Magazine, 13 Apr. 2024
All of this is done to have her body in a state of autophagy, which is the way our body moves out unnecessary and dysfunctional cellular components.
—Victoria Uwumarogie, Essence, 3 Oct. 2023
Cite this Entry
“Autophagy.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/autophagy. Accessed 15 Sep. 2025.
Copy CitationMedical Definition
autophagy
noun
au·toph·a·gy
ȯ-ˈtäf-ə-jē
plural autophagies
: digestion of cellular constituents by enzymes of the same cell
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