medical Definition of antifolate
- Folinic acid has been shown to be effective in preventing toxic reactions caused by antifolates while not reducing their therapeutic activity as antimalarial agents.
- —Elliott K. Main et al., The Journal of the American Medical Association, 17 June 1983
- The two drugs most widely used against malaria, particularly for prophylaxis, are chloroquine and the anti-folate pyrimethamine.
- —F.E.G. Cox, Nature, 17 Jan. 1991