dihydrofolate reductase


di·​hy·​dro·​fo·​late reductase -ˈfō-ˌlāt- How to pronounce dihydrofolate reductase (audio)
: an enzyme that catalyzes the reduction of a folate which has one of its rings with two double bonds and two attached hydrogen atoms into the dihydro form which differs only in having one double bond and four hydrogen atoms in the same ring

Note: Dihydrofolate reductase plays an important role in DNA synthesis and is targeted by some anticancer and antimicrobial drugs (such as methotrexate and trimethoprim) in order to inhibit its positive effect on cell growth and reproduction.

… an enzyme called dihydrofolate reductase or DHFR, a catalyst that is essential to nucleic acid synthesis and cell growth.Warren Froelich, The San Diego Union-Tribune
abbreviation DHFR

Dictionary Entries Near dihydrofolate reductase

Cite this Entry

“Dihydrofolate reductase.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/dihydrofolate%20reductase. Accessed 29 Jan. 2023.

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

Commonly Confused Words Quiz

  • vector image of a face with thought expression
  • I went to the ______ store to buy a birthday card.
How Strong Is Your Vocabulary?

Test your vocabulary with our 10-question quiz!

Solve today's spelling word game by finding as many words as you can with using just 7 letters. Longer words score more points.

Can you make 12 words with 7 letters?