meth·​o·​trex·​ate | \ ˌme-thə-ˈtrek-ˌsāt How to pronounce methotrexate (audio) \

Definition of methotrexate

: a toxic folic acid analog C20H22N8O5 that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

Examples of methotrexate in a Sentence

Recent Examples on the Web The standard of care for an ectopic pregnancy is to end it as soon as possible, either through surgery or by administering methotrexate, a drug that stops the cluster of fetal cells from further dividing. Wired, 7 Aug. 2022 Kristin Tevonian, who lives in suburban Illinois, faced a runaround when trying to refill her methotrexate script at Walgreens. Laura Weiss, The New Republic, 27 July 2022 Like Malone-King, Becky Schwartz takes methotrexate for a chronic condition. Jen Christensen, CNN, 22 July 2022 Jacobs depends on the drug methotrexate to treat her rheumatoid arthritis. Michael Hiltzik, Los Angeles Times, 19 July 2022 The decision to remove methotrexate from her care plan made absolutely no sense to her. Jen Christensen, CNN, 22 July 2022 If a woman is ready to become pregnant, the American Academy of Rheumatology recommends that methotrexate be stopped at least three months before conception. Dr. Erica Jalal, ABC News, 14 July 2022 However, those patients represent about 2% of the 5 million Americans who take methotrexate, according to the L.A. Times. Stephanie Emma Pfeffer,, 12 July 2022 Those patients represent about 2% of the 5 million Americans who take methotrexate. Sonja Sharpstaff Writer, Los Angeles Times, 11 July 2022 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'methotrexate.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of methotrexate

1955, in the meaning defined above

History and Etymology for methotrexate

meth- + -trexate, of unknown origin

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The first known use of methotrexate was in 1955

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Last Updated

10 Aug 2022

Cite this Entry

“Methotrexate.” Dictionary, Merriam-Webster, Accessed 13 Aug. 2022.

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More Definitions for methotrexate


meth·​o·​trex·​ate | \ ˌmeth-ə-ˈtrek-ˌsāt How to pronounce methotrexate (audio) \

Medical Definition of methotrexate

: a toxic drug C20H22N8O5 that is an analog of folic acid and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

called also amethopterin

More from Merriam-Webster on methotrexate Encyclopedia article about methotrexate


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