meth·​o·​trex·​ate | \ ˌme-thə-ˈtrek-ˌsāt How to pronounce methotrexate (audio) \

Definition of methotrexate

: a toxic folic acid analog C20H22N8O5 that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

Examples of methotrexate in a Sentence

Recent Examples on the Web

For more widespread disease, systemic therapy is generally required, which can involve either oral medication (like methotrexate, acitretin, or cyclosporine) or injectable biologic medications (like Enbrel, Humira or Stelara). Lambeth Hochwald,, "What to Know About Pustular Psoriasis, According to Dermatologists," 29 Aug. 2019 About the same time, inflammation-fighting corticosteroids such as methotrexate were introduced, further improving survival of children with ALL. Marie Mccullough,, "How conquering a rare leukemia in children revolutionized cancer care for millions," 6 June 2019 The man was switched to another drug for inflammatory arthritis, called methotrexate. Rachael Rettner, Fox News, "Why did the whites of this man's eyes turn blue?," 19 Apr. 2018 In the years prior to his death, Subbarow collaborated with Dr. Sidney Farber to develop methotrexate, the first effective chemotherapy against childhood leukemia. Aaron Gilbreath, Longreads, "We Are Scientists," 5 June 2018 Every week, Kendall Krick's father injects her with a chemotherapy drug called methotrexate. Richard Obert, azcentral, "Disease doesn't keep Seton's Kendall Krick from earning D-I scholarship," 9 Mar. 2018 This drug was a precursor to methotrexate, a treatment which provided the first cures of a metastatic cancer in 1956 and is still commonly used today. The Economist, "Knives, beams, drugs and antibodiesToday’s anti-cancer tools are ever better wielded," 14 Sep. 2017 Interestingly, both procedures [methotrexate and salpingostomy] are normally presented to patients exclusive of any moral considerations. Joanna Petrone, Longreads, "Pregnant, then Ruptured," 18 Aug. 2017 The most commonly used systemic medications for pediatric psoriasis include acitretin, methotrexate and cyclosporine, with the latter two drugs causing suppression of the immune system. Kate E. Oberlin, M.d., And Lawrence A. Schachner, M.d. Taking The Next Steps, miamiherald, "Your child has psoriasis, now how do you treat it?," 31 July 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'methotrexate.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of methotrexate

1955, in the meaning defined above

History and Etymology for methotrexate

meth- + -trexate, of unknown origin

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Last Updated

17 Sep 2019

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The first known use of methotrexate was in 1955

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meth·​o·​trex·​ate | \ ˌmeth-ə-ˈtrek-ˌsāt How to pronounce methotrexate (audio) \

Medical Definition of methotrexate

: a toxic drug C20H22N8O5 that is an analog of folic acid and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

called also amethopterin

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