methotrexate

noun

meth·​o·​trex·​ate ˌme-thə-ˈtrek-ˌsāt 

: a toxic folic acid analog C₂₀H₂₂N₈O₅ that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

Examples of methotrexate in a Sentence

Recent Examples on the Web

The protocol required that methotrexate be administered three or in some cases seven days prior to the misoprostol, rather than the typical 24-48 hours between mifepristone and misoprostol. — Christine Henneberg, STAT, 15 May 2026

Such an impairment can occur as a side effect of certain chemotherapy drugs, such as methotrexate. — ArsTechnica, 10 Mar. 2026

Examples include amiodarone, methotrexate, and black cohosh. — Health, 15 Dec. 2025

The case for leucovorin Until now, leucovorin has been prescribed primarily to protect healthy cells from the toxic effects of methotrexate, a common chemotherapy drug used in cancer care. — Jon Hamilton, NPR, 25 Sep. 2025

Word History

Etymology

meth- + -trexate, of unknown origin

First Known Use

1955, in the meaning defined above

Rhymes for methotrexate

• abbreviate
• accelerate
• accommodate
• accumulate
• acuminate
• adjudicate
• adulterate
• affiliate
• agglomerate
• agglutinate
• alleviate
• amalgamate

Medical Definition

methotrexate

noun

meth·​o·​trex·​ate ˌmeth-ə-ˈtrek-ˌsāt 

: a toxic drug C₂₀H₂₂N₈O₅ that is an analog of folate and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

called also amethopterin