meth·​o·​trex·​ate | \ ˌme-thə-ˈtrek-ˌsāt How to pronounce methotrexate (audio) \

Definition of methotrexate

: a toxic folic acid analog C20H22N8O5 that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

Examples of methotrexate in a Sentence

Recent Examples on the Web Luckily, there are other forms of DMARDs, such as JAK inhibitors, that may be an option if methotrexate isn’t effective enough. Joni Sweet, SELF, "Psoriatic Arthritis Medication: What You Need to Know," 13 Nov. 2020 One of the pills, methotrexate, stopped cancer cells from copying their DNA. Jessica Stuart, STAT, "I was a ‘nonadherent’ patient. That’s made me a more empathetic doctor," 6 Nov. 2020 Or, if methotrexate or other conventional DMARDS don’t bring your illness under control, your physician may suggest other treatments including biologics, JAK inhibitors, and steroids. Beth Krietsch, SELF, "5 Questions People With Rheumatoid Arthritis Should Ask Their Doctors," 26 Aug. 2020 If blood tests and X-rays show developments like highly elevated inflammatory markers and advanced bone erosion, your physician may choose an alternative rather than start you on methotrexate. Beth Krietsch, SELF, "5 Questions People With Rheumatoid Arthritis Should Ask Their Doctors," 26 Aug. 2020 If you were treated with methotrexate, pay attention to any pain after the injection. Annie Sneed, New York Times, "How to Recognize and Treat an Ectopic Pregnancy," 17 Apr. 2020 Systemic therapies for psoriasis include oral therapy (such as methotrexate, cyclosporine, oral retinoids, and apremilast) as well as numerous injectable biologic and biosimilar medications. Jenna Birch, SELF, "How to Find the Right Psoriasis Treatment for Your Symptoms," 28 Oct. 2019 At a follow-up appointment three days later, Gharachedaghi learned the methotrexate hadn’t dissolved the sac at all. Dave Quinn,, "Golnesa 'GG' Gharachedaghi Is Pregnant! Shahs of Sunset Star Expecting First Child," 4 Oct. 2019 For more widespread disease, systemic therapy is generally required, which can involve either oral medication (like methotrexate, acitretin, or cyclosporine) or injectable biologic medications (like Enbrel, Humira or Stelara). Lambeth Hochwald,, "What to Know About Pustular Psoriasis, According to Dermatologists," 29 Aug. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'methotrexate.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of methotrexate

1955, in the meaning defined above

History and Etymology for methotrexate

meth- + -trexate, of unknown origin

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Time Traveler for methotrexate

Time Traveler

The first known use of methotrexate was in 1955

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Last Updated

25 Nov 2020

Cite this Entry

“Methotrexate.” Dictionary, Merriam-Webster, Accessed 25 Nov. 2020.

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meth·​o·​trex·​ate | \ ˌmeth-ə-ˈtrek-ˌsāt How to pronounce methotrexate (audio) \

Medical Definition of methotrexate

: a toxic drug C20H22N8O5 that is an analog of folic acid and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

called also amethopterin

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