methotrexate

noun
meth·​o·​trex·​ate | \ˌme-thə-ˈtrek-ˌsāt \

Definition of methotrexate 

: a toxic folic acid analog C20H22N8O5 that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

Examples of methotrexate in a Sentence

Recent Examples on the Web

In the years prior to his death, Subbarow collaborated with Dr. Sidney Farber to develop methotrexate, the first effective chemotherapy against childhood leukemia. Aaron Gilbreath, Longreads, "We Are Scientists," 5 June 2018 Every week, Kendall Krick's father injects her with a chemotherapy drug called methotrexate. Richard Obert, azcentral, "Disease doesn't keep Seton's Kendall Krick from earning D-I scholarship," 9 Mar. 2018 This drug was a precursor to methotrexate, a treatment which provided the first cures of a metastatic cancer in 1956 and is still commonly used today. The Economist, "Knives, beams, drugs and antibodiesToday’s anti-cancer tools are ever better wielded," 14 Sep. 2017 Interestingly, both procedures [methotrexate and salpingostomy] are normally presented to patients exclusive of any moral considerations. Joanna Petrone, Longreads, "Pregnant, then Ruptured," 18 Aug. 2017 The most commonly used systemic medications for pediatric psoriasis include acitretin, methotrexate and cyclosporine, with the latter two drugs causing suppression of the immune system. Kate E. Oberlin, M.d., And Lawrence A. Schachner, M.d. Taking The Next Steps, miamiherald, "Your child has psoriasis, now how do you treat it?," 31 July 2017 Doctors treated him for rheumatoid arthritis, but a cocktail of medicines — including methotrexate, a chemotherapy drug given to cancer patients — proved ineffective. Adam Schupak, New York Times, "Improbable Return Makes Defense of Senior Open Title Possible," 29 June 2017 The note was tucked away in a file on methotrexate, a drug that can be used to end a pregnancy within the first seven weeks. Stephanie Russell-kraft, Marie Claire, "This Doctor Dropped Everything to Perform Abortions Full-Time," 13 June 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'methotrexate.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

See More

First Known Use of methotrexate

1955, in the meaning defined above

History and Etymology for methotrexate

meth- + -trexate, of unknown origin

Keep scrolling for more

Learn More about methotrexate

Share methotrexate

Statistics for methotrexate

Look-up Popularity

Time Traveler for methotrexate

The first known use of methotrexate was in 1955

See more words from the same year

Keep scrolling for more

More Definitions for methotrexate

methotrexate

noun
meth·​o·​trex·​ate | \ˌmeth-ə-ˈtrek-ˌsāt \

Medical Definition of methotrexate 

: a toxic drug C20H22N8O5 that is an analog of folic acid and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

called also amethopterin

More from Merriam-Webster on methotrexate

Britannica.com: Encyclopedia article about methotrexate

Comments on methotrexate

What made you want to look up methotrexate? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

playful or foolish behavior

Get Word of the Day daily email!

Test Your Vocabulary

Autumn Words of the Day 2018

  • a-top-down-image-of-road-through-an-autumn-forest
  • Which is a synonym of fugacious?
Spell It

Can you spell these 10 commonly misspelled words?

TAKE THE QUIZ
SCRABBLE® Sprint

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!