methotrexate

noun

meth·​o·​trex·​ate ˌme-thə-ˈtrek-ˌsāt How to pronounce methotrexate (audio)
: a toxic folic acid analog C20H22N8O5 that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

Examples of methotrexate in a Sentence

Recent Examples on the Web Typically costing tens of thousands of dollars annually, the drugs are prescribed after a patient fails to respond to older, cheaper drugs like methotrexate. Tribune News Service, Hartford Courant, 3 Jan. 2024 During the first month, the participants’ pain improved in both the placebo and methotrexate groups. Alyssa Hui, Verywell Health, 27 Oct. 2023 The recent study did not show methotrexate was any different. Alyssa Hui, Verywell Health, 27 Oct. 2023 The Biden administration is also working to increase the supply of methotrexate, which has been in shortage since March. Berkeley Lovelace Jr., NBC News, 25 Sep. 2023 Another chemotherapy drug also often used in children, methotrexate, has been in short supply since March, and is still hard to come by. Berkeley Lovelace Jr., NBC News, 25 Sep. 2023 However, two of your medicines, amiodarone and methotrexate, are both well-known for potentially causing lung disease. Dr. Keith Roach, oregonlive, 19 Sep. 2023 This includes various cancer drugs, such as methotrexate; antibiotics, such as penicillin and clindamycin; pain medications, such as morphine and lidocaine; and cardiac medication, such as atropine and digoxin. Gabrielle M. Etzel, Washington Examiner, 8 Sep. 2023 Isabella McDonald, then a junior at Utah Valley University, was diagnosed in April with a rare, often fatal bone cancer, whose sole treatment for young adults includes the drug methotrexate. Arthur Allen, Los Angeles Times, 21 June 2023 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'methotrexate.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

meth- + -trexate, of unknown origin

First Known Use

1955, in the meaning defined above

Time Traveler
The first known use of methotrexate was in 1955

Dictionary Entries Near methotrexate

Cite this Entry

“Methotrexate.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/methotrexate. Accessed 2 Mar. 2024.

Medical Definition

methotrexate

noun
meth·​o·​trex·​ate ˌmeth-ə-ˈtrek-ˌsāt How to pronounce methotrexate (audio)
: a toxic drug C20H22N8O5 that is an analog of folic acid and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

called also amethopterin

More from Merriam-Webster on methotrexate

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