meth·​o·​trex·​ate | \ ˌme-thə-ˈtrek-ˌsāt How to pronounce methotrexate (audio) \

Definition of methotrexate

: a toxic folic acid analog C20H22N8O5 that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

Examples of methotrexate in a Sentence

Recent Examples on the Web In patients who took azathioprine or methotrexate, the levels of antibodies against the virus were even lower. Julie Washington, cleveland, "Shift workers more likely to get severe COVID-19; common irritable bowel medications make vaccine less effective: Coronavirus update for April 29, 2021," 29 Apr. 2021 My husband comes home from work early to nurture me and reassure me everything will be OK. Cost: $8 for the methotrexate., "Fertility Diary: 2 Rounds Of IVF & Chronic Endometritis," 30 Nov. 2020 Luckily, there are other forms of DMARDs, such as JAK inhibitors, that may be an option if methotrexate isn’t effective enough. Joni Sweet, SELF, "Psoriatic Arthritis Medication: What You Need to Know," 13 Nov. 2020 One of the pills, methotrexate, stopped cancer cells from copying their DNA. Jessica Stuart, STAT, "I was a ‘nonadherent’ patient. That’s made me a more empathetic doctor," 6 Nov. 2020 Or, if methotrexate or other conventional DMARDS don’t bring your illness under control, your physician may suggest other treatments including biologics, JAK inhibitors, and steroids. Beth Krietsch, SELF, "5 Questions People With Rheumatoid Arthritis Should Ask Their Doctors," 26 Aug. 2020 If blood tests and X-rays show developments like highly elevated inflammatory markers and advanced bone erosion, your physician may choose an alternative rather than start you on methotrexate. Beth Krietsch, SELF, "5 Questions People With Rheumatoid Arthritis Should Ask Their Doctors," 26 Aug. 2020 If you were treated with methotrexate, pay attention to any pain after the injection. Annie Sneed, New York Times, "How to Recognize and Treat an Ectopic Pregnancy," 17 Apr. 2020 Systemic therapies for psoriasis include oral therapy (such as methotrexate, cyclosporine, oral retinoids, and apremilast) as well as numerous injectable biologic and biosimilar medications. Jenna Birch, SELF, "How to Find the Right Psoriasis Treatment for Your Symptoms," 28 Oct. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'methotrexate.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of methotrexate

1955, in the meaning defined above

History and Etymology for methotrexate

meth- + -trexate, of unknown origin

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Time Traveler for methotrexate

Time Traveler

The first known use of methotrexate was in 1955

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Statistics for methotrexate

Last Updated

6 May 2021

Cite this Entry

“Methotrexate.” Dictionary, Merriam-Webster, Accessed 12 May. 2021.

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More Definitions for methotrexate


meth·​o·​trex·​ate | \ ˌmeth-ə-ˈtrek-ˌsāt How to pronounce methotrexate (audio) \

Medical Definition of methotrexate

: a toxic drug C20H22N8O5 that is an analog of folic acid and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

called also amethopterin

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