Medical Dictionary


noun ami·no·glu·teth·i·mide \-glü-ˈteth-ə-ˌmīd\

Medical Definition of aminoglutethimide

  1. :  a drug C13H16N2O2 that inhibits the production of steroids by the adrenal cortex by blocking the conversion of cholesterol to pregnenolone and is used chiefly in the treatment of Cushing's disease Aminoglutethimide is a derivative of glutethimide and has also been used as an aromatase inhibitor to treat cancers of the breast and prostate. Direct comparisons between aminoglutethimide therapy and surgical adrenalectomy have documented equivalence …—Gabriel N. Hortobagyi, in Principles and Practice of Endocrinology and Metabolism, 2001

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to criticize severely

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