Medical Dictionary

Müllerian inhibiting substance

noun Müllerian in·hib·it·ing substance \ -in-ˌhib-ət-iŋ- \

variants: or Mullerian inhibiting substance also müllerian inhibiting substance or mullerian inhibiting substance

medical Definition of Müllerian inhibiting substance

: a glycoprotein hormone produced by the Sertoli cells of the male testis during fetal development that causes regression and atrophy of the Müllerian ducts : anti-mullerian hormone —abbreviation MIS

Biographical Note for müllerian inhibiting substance

Müller, Johannes Peter (1801–1858), German physiologist and anatomist. Müller is generally acclaimed as one of the greatest biologists of all time. In 1834–40 he published a handbook of physiology that ranks as the first great text on that subject produced in the 19th century. In histology he described the microscopic anatomy of a large series of secreting glands. He was the first to classify the excretory system of the glands as an independent system of tubes; he noted that the blood vessels formed only a capillary network. He described the Müllerian duct in 1825.