virulent

adjective

vir·​u·​lent ˈvir-ə-lənt 

ˈvir-yə-

1

a

: marked by a rapid, severe, and destructive course

a virulent infection

b

: able to overcome bodily defensive mechanisms : markedly pathogenic

virulent bacteria

2

: extremely poisonous or venomous

3

: full of malice : malignant

virulent racists

4

: objectionably harsh or strong

virulent criticism

virulently adverb

Synonyms

• bad [slang]
• bitchy
• catty
• cruel
• despiteful
• hateful
• malevolent
• malicious
• malign
• malignant
• mean
• nasty
• spiteful
• vicious

Examples of virulent in a Sentence

The country seemed to be returning to the virulent nationalism of its past.

the virulent look on her face warned me that she was about to say something unkind

Recent Examples on the Web

Helene left many lessons to be learned among inland communities in the paths of increasingly virulent storms. —Jennifer Berry Hawes, ProPublica, 21 May 2025

Just then, however, a virulent backlash against generative A.I. swept through Hollywood. —Brooks Barnes, New York Times, 21 May 2025

The virulent Delta variant, for example, appeared in the spring of 2021 and was overtaken by the Omicron variant, which also caused severe disease, that November. —Michael Hiltzik, Los Angeles Times, 8 May 2025

After being the target of virulent antisemitism as a child and while grappling with drug addiction as a young man, Isaacs stumbled into acting — and quickly made a name for himself. —Scott Feinberg, HollywoodReporter, 21 Apr. 2025

Word History

Etymology

Middle English, "discharging watery pus, purulent," borrowed from Latin vīrulentus "full of poison, venomous," from vīrus "venom, poisonous fluid" + -ulentus "having in quantity, full of" — more at virus

First Known Use

14th century, in the meaning defined at sense 1a

Phrases Containing virulent

• hyper-virulent

Rhymes for virulent

• avirulent

Kids Definition

virulent

adjective

vir·​u·​lent ˈvir-(y)ə-lənt 

1

a

: marked by a rapid, severe, and often deadly course

a virulent infection

b

: able to overcome or break down the defenses of the body

a virulent germ

2

: extremely poisonous : noxious

3

: full of hate : spiteful

virulently adverb

Medical Definition

virulent

adjective

vir·​u·​lent -lənt 

1

a

: marked by a rapid, severe, and malignant course

a virulent infection

b

: able to overcome bodily defense mechanisms

a virulent pathogen

2

: extremely poisonous or venomous : noxious